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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM120A

Summary for FAM120A

Gene information	Gene symbol	FAM120A
	Ensembl ID	ENSG00000048828
	Entrez ID	23196
	Gene name	family with sequence similarity 120A
	Synonyms	C9orf10\|KIAA0183\|OSSA
	Gene type	protein_coding
	UniProtAcc	Q9NZB2

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Dataset with differentially expressed gene: FAM120A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.288446	2.28e-09
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.338009	1.19e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.485884	1.34e-38
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.266745	3.49e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.285557	2.15e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.468493	0.00e+00

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Expression of FAM120A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM120A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM120A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM120A	hsa-miR-6809-3p	98.3996	NM_001286722
FAM120A	hsa-miR-7856-5p	97.7466	NM_001286722
FAM120A	hsa-miR-4698	97.6225	NM_001286722
FAM120A	hsa-miR-6882-5p	97.4508	NM_001286724
FAM120A	hsa-miR-4289	96.5761	NM_001286722
FAM120A	hsa-miR-12132	96.3157	NM_001286722
FAM120A	hsa-miR-4753-3p	96.205	NM_001286722
FAM120A	hsa-miR-6833-3p	95.7863	NM_001286722
FAM120A	hsa-miR-4503	95.5141	NM_001286722
FAM120A	hsa-miR-3163	95.2033	NM_001286724
FAM120A	hsa-miR-551b-5p	95.0362	NM_001286722
FAM120A	hsa-miR-5689	94.5027	NM_001286722
FAM120A	hsa-miR-4768-5p	94.1576	NM_001286722
FAM120A	hsa-miR-582-5p	93.5405	NM_001286724
FAM120A	hsa-miR-562	93.198	NM_001286724
FAM120A	hsa-miR-4762-3p	93.149	NM_001286722
FAM120A	hsa-miR-5011-5p	93.0596	NM_001286724
FAM120A	hsa-miR-8063	92.9965	NM_001286722
FAM120A	hsa-miR-6507-5p	92.8492	NM_001286722
FAM120A	hsa-miR-3658	92.5174	NM_001286722
FAM120A	hsa-miR-590-3p	92.3324	NM_001286724
FAM120A	hsa-miR-153-5p	92.1726	NM_001286722
FAM120A	hsa-miR-1252-5p	91.7812	NM_001286724
FAM120A	hsa-miR-495-5p	91.4309	NM_001286722
FAM120A	hsa-miR-186-5p	91.0307	NM_001286722
FAM120A	hsa-miR-409-3p	90.9549	NM_001286722
FAM120A	hsa-miR-19a-5p	90.6971	NM_001286722
FAM120A	hsa-miR-19b-2-5p	90.6971	NM_001286722
FAM120A	hsa-miR-19b-1-5p	90.6971	NM_001286722
FAM120A	hsa-miR-6126	90.4559	NM_001286722
FAM120A	hsa-miR-5700	90.4197	NM_001286722
FAM120A	hsa-miR-6865-3p	90.3895	NM_001286722
FAM120A	hsa-miR-605-3p	90.2201	NM_001286722
FAM120A	hsa-miR-130a-5p	90.0499	NM_001286722
FAM120A	hsa-miR-8066	89.9504	NM_001286724
FAM120A	hsa-miR-7109-5p	89.8932	NM_001286722
FAM120A	hsa-miR-12130	89.8132	NM_001286724
FAM120A	hsa-miR-3192-3p	89.4687	NM_001286722
FAM120A	hsa-miR-147b-5p	89.2815	NM_001286722
FAM120A	hsa-miR-1468-3p	89.0679	NM_001286722
FAM120A	hsa-miR-4261	88.9734	NM_001286722
FAM120A	hsa-miR-10394-5p	88.4358	NM_001286724
FAM120A	hsa-miR-1205	88.4358	NM_001286724
FAM120A	hsa-miR-29a-5p	88.1515	NM_001286722
FAM120A	hsa-miR-4433a-3p	88.0649	NM_001286724
FAM120A	hsa-miR-5692a	87.9898	NM_001286724
FAM120A	hsa-miR-3671	87.7085	NM_001286724
FAM120A	hsa-miR-603	87.5204	NM_001286722
FAM120A	hsa-miR-4489	87.3757	NM_001286724
FAM120A	hsa-miR-548l	87.3398	NM_001286722

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Motifs and transcription factors (TFs) regulating FAM120A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM120A	hdpi__ETS1	ETS1 (directAnnotation).
FAM120A	kznf__ZNF737_Imbeault2017_OM_MEME	ZNF737 (directAnnotation).
FAM120A	jaspar__MA1933.1	SREBF2 (directAnnotation).
FAM120A	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."