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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM107B

Summary for FAM107B

Gene information	Gene symbol	FAM107B
	Ensembl ID	ENSG00000065809
	Entrez ID	83641
	Gene name	family with sequence similarity 107 member B
	Synonyms	C10orf45\|FLJ45505\|HITS\|MGC11034
	Gene type	protein_coding
	UniProtAcc	Q9H098

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Dataset with differentially expressed gene: FAM107B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.510205	1.15e-07
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.74793	2.80e-45
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	-0.374251	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.382555	1.59e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	NK cells	0.42244	6.72e-05
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.457194	6.43e-31
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.331205	7.07e-33
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.262329	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.350709	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.686062	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.645383	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.637803	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.250747	1.62e-14
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.27918	0.00e+00

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Expression of FAM107B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM107B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM107B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM107B	hsa-miR-190a-3p	99.2665	NM_001282695
FAM107B	hsa-miR-330-3p	96.5612	NM_001320738
FAM107B	hsa-miR-3148	96.191	NM_001282695
FAM107B	hsa-miR-5011-5p	95.9399	NM_001320738
FAM107B	hsa-miR-10522-5p	95.8496	NM_001282695
FAM107B	hsa-miR-6507-5p	95.5228	NM_001282695
FAM107B	hsa-miR-659-3p	94.1437	NM_001320738
FAM107B	hsa-miR-3658	92.9823	NM_001282695
FAM107B	hsa-miR-4435	92.5937	NM_001320738
FAM107B	hsa-miR-182-3p	92.0753	NM_001320738
FAM107B	hsa-miR-656-3p	90.8345	NM_001282695
FAM107B	hsa-miR-3160-5p	90.704	NM_001320738
FAM107B	hsa-miR-4696	88.4378	NM_001282695
FAM107B	hsa-miR-432-5p	87.2176	NM_001320738
FAM107B	hsa-miR-3692-5p	87.1197	NM_001282695
FAM107B	hsa-miR-300	86.5742	NM_001320738
FAM107B	hsa-miR-381-3p	86.5742	NM_001320738
FAM107B	hsa-miR-4477a	86.3853	NM_001320738
FAM107B	hsa-miR-4324	86.3471	NM_001282695
FAM107B	hsa-miR-208a-5p	86.213	NM_001320738
FAM107B	hsa-miR-208b-5p	86.213	NM_001320738
FAM107B	hsa-miR-6504-5p	85.64	NM_001282695
FAM107B	hsa-miR-3064-5p	85.64	NM_001282695
FAM107B	hsa-miR-3085-3p	85.64	NM_001282695
FAM107B	hsa-miR-577	85.463	NM_001320738
FAM107B	hsa-miR-6882-5p	85.2048	NM_001320738
FAM107B	hsa-miR-335-5p	85.2035	NM_001320738
FAM107B	hsa-miR-4276	84.457	NM_001320738
FAM107B	hsa-miR-152-5p	83.3902	NM_001320738
FAM107B	hsa-miR-1200	83.1439	NM_001282695
FAM107B	hsa-miR-4695-3p	81.7178	NM_001320738
FAM107B	hsa-miR-8075	81.6943	NM_001320738
FAM107B	hsa-miR-520e-5p	81.4749	NM_001282695
FAM107B	hsa-miR-3672	80.8962	NM_001320738
FAM107B	hsa-miR-5197-3p	80.5444	NM_001282695
FAM107B	hsa-miR-10393-5p	80.3195	NM_001320738
FAM107B	hsa-miR-7114-5p	80.247	NM_001282695

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Motifs and transcription factors (TFs) regulating FAM107B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM107B	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
FAM107B	metacluster_122.17	IRF6 (directAnnotation).
FAM107B	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
FAM107B	taipale_tf_pairs__TFAP4_DLX3_NNCAGCTGNNNNNNNTAATTN_HT	DLX3; TFAP4 (directAnnotation).
FAM107B	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
FAM107B	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
FAM107B	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
FAM107B	transfac_pro__M04844	MAX (directAnnotation).
FAM107B	transfac_public__M00205	NR3C1 (directAnnotation).
FAM107B	metacluster_8.1	ZNF382 (directAnnotation).
FAM107B	taipale_tf_pairs__TEAD4_ELK1_RGAATSCGGAAGYN_CAP	ELK1; TEAD4 (directAnnotation).
FAM107B	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
FAM107B	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
FAM107B	transfac_public__M00278	GATA1; LDB1; LMO2; TAL1; TCF3 (inferredBy_Orthology).
FAM107B	metacluster_78.20	PAX7 (inferredBy_Orthology).
FAM107B	transfac_pro__M05768	ZNF544 (directAnnotation).
FAM107B	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
FAM107B	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
FAM107B	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
FAM107B	transfac_pro__M06213	ZNF267 (directAnnotation).
FAM107B	transfac_pro__M06035	ZNF749 (directAnnotation).
FAM107B	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
FAM107B	metacluster_52.11	ZNF184 (directAnnotation).
FAM107B	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
FAM107B	metacluster_98.1	ZNF524 (directAnnotation).
FAM107B	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
FAM107B	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
FAM107B	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
FAM107B	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
FAM107B	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
FAM107B	metacluster_72.1	ZNF423; ZNF423 (directAnnotation).
FAM107B	transfac_pro__M06951	TEF (directAnnotation).
FAM107B	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
FAM107B	jaspar__MA1957.1	ELK1 (directAnnotation).
FAM107B	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
FAM107B	transfac_pro__M00733	SMAD4 (directAnnotation).
FAM107B	transfac_pro__M07387	ZBTB7A (directAnnotation).
FAM107B	transfac_pro__M06766	ZNF835 (directAnnotation).
FAM107B	taipale_tf_pairs__TEAD4_ELK3_NCCGGAANNNNNNNMATWCC_CAP_repr	ELK3; TEAD4 (directAnnotation).
FAM107B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM107B	transfac_pro__M00716	ZBTB14 (directAnnotation).
FAM107B	cisbp__M00343	PAX6 (directAnnotation).
FAM107B	hdpi__NRL	NRL (directAnnotation).
FAM107B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FAM107B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM107B	transfac_pro__M04916	TAF1 (directAnnotation).
FAM107B	transfac_pro__M04617	ZBTB7A (directAnnotation).
FAM107B	transfac_pro__M07611	NONO (directAnnotation).
FAM107B	transfac_pro__M02898	SMAD3 (directAnnotation).
FAM107B	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."