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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM102A

Summary for FAM102A

Gene information	Gene symbol	FAM102A
	Ensembl ID	ENSG00000167106
	Entrez ID	399665
	Gene name	family with sequence similarity 102 member A
	Synonyms	bA203J24.7\|C9orf132\|Eeig1\|SYM-3A
	Gene type	protein_coding
	UniProtAcc	Q5T9C2

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Dataset with differentially expressed gene: FAM102A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.422324	2.04e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.371274	6.36e-32
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.672429	0.00e+00

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Expression of FAM102A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM102A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM102A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM102A	hsa-miR-206	96.1377	NM_001035254
FAM102A	hsa-miR-1-3p	96.1377	NM_001035254
FAM102A	hsa-miR-486-3p	95.0829	NM_001035254
FAM102A	hsa-miR-613	91.9554	NM_001035254
FAM102A	hsa-miR-106b-5p	91.8926	NM_001035254
FAM102A	hsa-miR-20a-5p	91.8926	NM_001035254
FAM102A	hsa-miR-765	91.7534	NM_001035254
FAM102A	hsa-miR-106a-5p	90.7662	NM_001035254
FAM102A	hsa-miR-526b-3p	90.6742	NM_001035254
FAM102A	hsa-miR-17-5p	90.6023	NM_001035254
FAM102A	hsa-miR-519d-3p	90.6023	NM_001035254
FAM102A	hsa-miR-93-5p	90.6023	NM_001035254
FAM102A	hsa-miR-20b-5p	90.6023	NM_001035254
FAM102A	hsa-miR-6721-5p	90.4196	NM_001035254
FAM102A	hsa-miR-5589-5p	89.7773	NM_001035254
FAM102A	hsa-miR-6825-5p	89.415	NM_001035254
FAM102A	hsa-miR-7106-5p	89.3201	NM_001035254
FAM102A	hsa-miR-6837-5p	88.7625	NM_001035254
FAM102A	hsa-miR-4695-5p	88.508	NM_001035254
FAM102A	hsa-miR-4728-5p	88.2095	NM_001035254
FAM102A	hsa-miR-3179	87.5342	NM_001035254
FAM102A	hsa-miR-203a-5p	87.1853	NM_001035254
FAM102A	hsa-miR-4685-5p	86.9571	NM_001035254
FAM102A	hsa-miR-11181-3p	86.8519	NM_001035254
FAM102A	hsa-miR-6849-3p	86.69	NM_001035254
FAM102A	hsa-miR-19a-3p	86.1132	NM_001035254
FAM102A	hsa-miR-19b-3p	86.1132	NM_001035254
FAM102A	hsa-miR-140-5p	86.0497	NM_001035254
FAM102A	hsa-miR-3612	85.9858	NM_001035254
FAM102A	hsa-miR-1255b-5p	85.7822	NM_001035254
FAM102A	hsa-miR-1255a	85.7822	NM_001035254
FAM102A	hsa-miR-6785-5p	85.3661	NM_001035254
FAM102A	hsa-miR-153-3p	85.2538	NM_001035254
FAM102A	hsa-miR-3148	84.9435	NM_001035254
FAM102A	hsa-miR-6743-5p	84.3637	NM_001035254
FAM102A	hsa-miR-4688	84.3637	NM_001035254
FAM102A	hsa-miR-4515	83.9032	NM_001035254
FAM102A	hsa-miR-504-3p	83.4213	NM_001035254
FAM102A	hsa-miR-216a-3p	82.9546	NM_001035254
FAM102A	hsa-miR-543	82.8621	NM_001035254
FAM102A	hsa-miR-1226-3p	82.6333	NM_001035254
FAM102A	hsa-miR-650	82.1342	NM_001035254
FAM102A	hsa-miR-122-5p	81.9601	NM_001035254
FAM102A	hsa-miR-4731-5p	81.877	NM_001035254
FAM102A	hsa-miR-3934-3p	81.814	NM_001035254
FAM102A	hsa-miR-6847-5p	80.9846	NM_001035254

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Motifs and transcription factors (TFs) regulating FAM102A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM102A	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
FAM102A	transfac_pro__M01252	E2F6 (directAnnotation).
FAM102A	jaspar__MA1125.1	ZNF384 (directAnnotation).
FAM102A	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
FAM102A	taipale_tf_pairs__HOXB2_SOX15_ACAAWRSNNNNYMATTA_CAP_repr	HOXB2; SOX15 (directAnnotation).
FAM102A	tfdimers__MD00225	NKX6-2; POU5F1 (directAnnotation).
FAM102A	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
FAM102A	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
FAM102A	transfac_pro__M03849	SOX4 (directAnnotation).
FAM102A	metacluster_145.6	ZNF79; ZNF79 (directAnnotation).
FAM102A	tfdimers__MD00454	ARID3A; PAX4 (directAnnotation).
FAM102A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM102A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FAM102A	transfac_pro__M01253	CNOT3 (directAnnotation).
FAM102A	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."