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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAAP20

Summary for FAAP20

Gene information	Gene symbol	FAAP20
	Ensembl ID	ENSG00000162585
	Entrez ID	199990
	Gene name	FA core complex associated protein 20
	Synonyms	C1orf86\|FLJ31031
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FAAP20

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.327528	1.84e-24
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.998904	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.691651	0.00e+00

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Expression of FAAP20 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAAP20

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAAP20

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAAP20	hsa-miR-3135b	93.3977	NM_001282673
FAAP20	hsa-miR-6512-3p	91.5469	NM_001282673
FAAP20	hsa-miR-6720-5p	91.5469	NM_001282673
FAAP20	hsa-miR-4516	88.8516	NM_001282673
FAAP20	hsa-miR-186-3p	85.3456	NM_001256946
FAAP20	hsa-miR-6787-5p	83.0255	NM_001282670
FAAP20	hsa-miR-6757-5p	81.7642	NM_001282673
FAAP20	hsa-miR-3928-3p	81.4167	NM_001282673
FAAP20	hsa-miR-4434	81.3529	NM_001282673
FAAP20	hsa-miR-5703	81.3529	NM_001282673

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Motifs and transcription factors (TFs) regulating FAAP20

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAAP20	metacluster_113.4	MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology).
FAAP20	transfac_pro__M05798	ZNF517 (directAnnotation).
FAAP20	transfac_pro__M06643	ZNF583 (directAnnotation).
FAAP20	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
FAAP20	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
FAAP20	transfac_pro__M05550	SNAPC4 (inferredBy_Orthology).
FAAP20	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
FAAP20	transfac_pro__M04826	EP300 (directAnnotation).
FAAP20	jaspar__MA1933.1	SREBF2 (directAnnotation).
FAAP20	swissregulon__hs__ELF2	ELF2 (directAnnotation).
FAAP20	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
FAAP20	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
FAAP20	cisbp__M08198	ELF1 (directAnnotation).
FAAP20	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
FAAP20	transfac_pro__M04748	GABPA (directAnnotation).
FAAP20	transfac_public__M00041	ATF2; JUN (directAnnotation).
FAAP20	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."