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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: F2RL1

Summary for F2RL1

Gene information	Gene symbol	F2RL1
	Ensembl ID	ENSG00000164251
	Entrez ID	2150
	Gene name	F2R like trypsin receptor 1
	Synonyms	GPR11\|PAR2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: F2RL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.02452	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.365541	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.259172	4.59e-21
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.70838	0.00e+00

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Expression of F2RL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to F2RL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating F2RL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
F2RL1	hsa-miR-5011-5p	99.0579	NM_005242
F2RL1	hsa-let-7b-3p	90.6713	NM_005242
F2RL1	hsa-miR-98-3p	90.6713	NM_005242
F2RL1	hsa-let-7f-1-3p	90.6713	NM_005242
F2RL1	hsa-let-7a-3p	90.6713	NM_005242
F2RL1	hsa-miR-4275	88.1619	NM_005242
F2RL1	hsa-miR-190a-3p	87.8706	NM_005242
F2RL1	hsa-miR-944	83.4026	NM_005242
F2RL1	hsa-miR-4666a-5p	81.5133	NM_005242
F2RL1	hsa-miR-888-3p	80.607	NM_005242

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Motifs and transcription factors (TFs) regulating F2RL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
F2RL1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
F2RL1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
F2RL1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
F2RL1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
F2RL1	metacluster_135.11	NR2C2 (directAnnotation).
F2RL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
F2RL1	metacluster_7.13	ZFX (directAnnotation).
F2RL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
F2RL1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
F2RL1	metacluster_198.3	ZFP64 (directAnnotation).
F2RL1	cisbp__M00788	ZFY (inferredBy_Orthology).
F2RL1	transfac_pro__M03806	ZBTB7C (directAnnotation).
F2RL1	metacluster_182.10	ZFX (directAnnotation).
F2RL1	transfac_pro__M00492	STAT1 (directAnnotation).
F2RL1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
F2RL1	hdpi__ELF2	ELF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."