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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: F13A1

Summary for F13A1

Gene information	Gene symbol	F13A1
	Ensembl ID	ENSG00000124491
	Entrez ID	2162
	Gene name	coagulation factor XIII A chain
	Synonyms	F13A
	Gene type	protein_coding
	UniProtAcc	P00488

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Dataset with differentially expressed gene: F13A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.290933	7.25e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.297186	1.01e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.888032	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.344073	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.360707	6.84e-18
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.276685	0.00e+00

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Expression of F13A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to F13A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating F13A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
F13A1	hsa-miR-105-5p	98.124	NM_000129
F13A1	hsa-miR-7853-5p	98.124	NM_000129
F13A1	hsa-miR-6865-3p	93.7452	NM_000129
F13A1	hsa-miR-764	91.8974	NM_000129
F13A1	hsa-miR-3171	91.8416	NM_000129
F13A1	hsa-miR-3682-3p	91.6268	NM_000129
F13A1	hsa-miR-556-5p	90.3362	NM_000129
F13A1	hsa-miR-3665	90.0376	NM_000129
F13A1	hsa-miR-4256	88.8151	NM_000129
F13A1	hsa-miR-11181-5p	88.8151	NM_000129
F13A1	hsa-miR-182-5p	88.4094	NM_000129
F13A1	hsa-miR-4698	88.2579	NM_000129
F13A1	hsa-miR-7150	86.4756	NM_000129
F13A1	hsa-miR-9983-3p	86.1063	NM_000129
F13A1	hsa-miR-5681a	85.8325	NM_000129
F13A1	hsa-miR-335-5p	84.9515	NM_000129
F13A1	hsa-miR-129-5p	81.3707	NM_000129
F13A1	hsa-miR-548p	81.3588	NM_000129

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Motifs and transcription factors (TFs) regulating F13A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
F13A1	metacluster_22.37	BACH1 (directAnnotation).
F13A1	metacluster_22.34	BACH2 (directAnnotation).
F13A1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
F13A1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
F13A1	tfdimers__MD00276	IRF1; STAT6 (directAnnotation).
F13A1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
F13A1	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
F13A1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
F13A1	tfdimers__MD00183	CRX; YY1 (directAnnotation).
F13A1	tfdimers__MD00394	CDX2; PAX4 (directAnnotation).
F13A1	kznf__ZNF33B_Imbeault2017_RP_RCADE	ZNF33B (directAnnotation).
F13A1	transfac_pro__M06763	ZNF225 (directAnnotation).
F13A1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
F13A1	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
F13A1	cisbp__M02645	ETS1 (directAnnotation).
F13A1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
F13A1	transfac_pro__M05515	ZNF280B (directAnnotation).
F13A1	tfdimers__MD00049	MYB; OTX1; OTX2 (directAnnotation).
F13A1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
F13A1	transfac_pro__M06863	ZNF789 (directAnnotation).
F13A1	taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr	PITX1; TBX21 (directAnnotation).
F13A1	transfac_pro__M06302	ZNF506 (directAnnotation).
F13A1	transfac_pro__M05542	SNAPC4 (directAnnotation).
F13A1	tfdimers__MD00223	SOX9; TEAD1 (directAnnotation).
F13A1	transfac_pro__M06732	ZNF304 (directAnnotation).
F13A1	transfac_pro__M05701	ZNF30 (directAnnotation).
F13A1	transfac_pro__M06048	ZNF208 (directAnnotation).
F13A1	jaspar__MA0035.4	GATA1 (directAnnotation).
F13A1	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
F13A1	transfac_pro__M05842	ZBTB41 (inferredBy_Orthology).
F13A1	metacluster_131.2	ZNF257 (directAnnotation).
F13A1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
F13A1	metacluster_141.4	GLIS2 (directAnnotation).
F13A1	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
F13A1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
F13A1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
F13A1	"Anti-inhibitor coagulant complex"	DB13151	biotech
F13A1	"Human thrombin"	DB11571	biotech
F13A1	"N-Acetyl-Serine"	DB02340	small molecule
F13A1	"Prothrombin"	DB11311	biotech
F13A1	"Thrombin"	DB11300	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."