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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EVI2A

Summary for EVI2A

Gene information	Gene symbol	EVI2A
	Ensembl ID	ENSG00000126860
	Entrez ID	2123
	Gene name	ecotropic viral integration site 2A
	Synonyms	EVDA\|EVI2
	Gene type	protein_coding
	UniProtAcc	P22794

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Dataset with differentially expressed gene: EVI2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.257885	1.07e-25
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.283681	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.467295	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.367118	0.00e+00

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Expression of EVI2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EVI2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EVI2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EVI2A	hsa-miR-8485	99.2428	NM_001003927
EVI2A	hsa-miR-670-3p	95.5618	NM_001003927
EVI2A	hsa-miR-548ay-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548au-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548ae-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548ak	93.6709	NM_001003927
EVI2A	hsa-miR-548d-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548w	93.6709	NM_001003927
EVI2A	hsa-miR-548c-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548y	93.6709	NM_001003927
EVI2A	hsa-miR-548ar-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548o-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548am-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548b-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548h-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548ad-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548bb-5p	93.6709	NM_001003927
EVI2A	hsa-miR-548aq-5p	93.6103	NM_001003927
EVI2A	hsa-miR-12135	93.1386	NM_001003927
EVI2A	hsa-miR-548ab	92.9999	NM_001003927
EVI2A	hsa-miR-548j-5p	92.9999	NM_001003927
EVI2A	hsa-miR-548as-5p	92.9999	NM_001003927
EVI2A	hsa-miR-548ap-5p	92.9999	NM_001003927
EVI2A	hsa-miR-548i	92.9999	NM_001003927
EVI2A	hsa-miR-548a-5p	92.9999	NM_001003927
EVI2A	hsa-miR-617	92.7585	NM_001003927
EVI2A	hsa-miR-559	92.5002	NM_001003927
EVI2A	hsa-miR-1303	91.7639	NM_001003927
EVI2A	hsa-miR-2117	91.0368	NM_001003927
EVI2A	hsa-miR-7111-3p	89.651	NM_001003927
EVI2A	hsa-miR-6826-3p	87.1003	NM_001003927
EVI2A	hsa-miR-12126	85.4174	NM_001003927
EVI2A	hsa-miR-26a-1-3p	83.8461	NM_001003927
EVI2A	hsa-miR-26a-2-3p	83.8461	NM_001003927
EVI2A	hsa-miR-3154	82.3616	NM_001003927
EVI2A	hsa-miR-4775	81.8884	NM_001003927
EVI2A	hsa-miR-4672	81.6026	NM_001003927
EVI2A	hsa-miR-4711-5p	80.9983	NM_001003927
EVI2A	hsa-miR-6733-3p	80.9233	NM_001003927
EVI2A	hsa-miR-4682	80.7387	NM_001003927

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Motifs and transcription factors (TFs) regulating EVI2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EVI2A	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
EVI2A	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
EVI2A	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
EVI2A	transfac_pro__M04722	SPI1 (directAnnotation).
EVI2A	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
EVI2A	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."