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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ETV5

Summary for ETV5

Gene information	Gene symbol	ETV5
	Ensembl ID	ENSG00000244405
	Entrez ID	2119
	Gene name	ETS variant transcription factor 5
	Synonyms	ERM
	Gene type	protein_coding
	UniProtAcc	P41161

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Dataset with differentially expressed gene: ETV5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.477134	3.82e-40
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.28665	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.31702	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.280129	0.00e+00

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Expression of ETV5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ETV5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ETV5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ETV5	hsa-miR-3120-3p	98.6068	NM_004454
ETV5	hsa-miR-3910	95.4982	NM_004454
ETV5	hsa-miR-1284	95.3558	NM_004454
ETV5	hsa-miR-6716-5p	93.0398	NM_004454
ETV5	hsa-miR-5701	92.9933	NM_004454
ETV5	hsa-miR-9983-3p	92.3093	NM_004454
ETV5	hsa-miR-518c-5p	91.357	NM_004454
ETV5	hsa-miR-129-5p	91.0627	NM_004454
ETV5	hsa-miR-7159-5p	90.2199	NM_004454
ETV5	hsa-miR-3529-3p	88.6886	NM_004454
ETV5	hsa-miR-548ap-3p	88.6865	NM_004454
ETV5	hsa-miR-548aa	88.6865	NM_004454
ETV5	hsa-miR-548t-3p	88.6865	NM_004454
ETV5	hsa-miR-4296	88.5435	NM_004454
ETV5	hsa-let-7c-3p	88.4285	NM_004454
ETV5	hsa-miR-4666b	88.0279	NM_004454
ETV5	hsa-miR-6886-3p	87.6324	NM_004454
ETV5	hsa-miR-875-3p	87.4892	NM_004454
ETV5	hsa-miR-4793-3p	87.128	NM_004454
ETV5	hsa-miR-6881-5p	86.5821	NM_004454
ETV5	hsa-miR-589-5p	86.2841	NM_004454
ETV5	hsa-miR-6894-3p	86.0488	NM_004454
ETV5	hsa-miR-4322	85.3103	NM_004454
ETV5	hsa-miR-4265	85.3103	NM_004454
ETV5	hsa-miR-1305	85.043	NM_004454
ETV5	hsa-miR-19b-3p	84.8897	NM_004454
ETV5	hsa-miR-19a-3p	84.8897	NM_004454
ETV5	hsa-miR-1283	84.888	NM_004454
ETV5	hsa-miR-10527-5p	84.5037	NM_004454
ETV5	hsa-miR-6514-3p	84.2819	NM_004454
ETV5	hsa-miR-520a-5p	84.1739	NM_004454
ETV5	hsa-miR-525-5p	84.1739	NM_004454
ETV5	hsa-miR-4782-3p	84.1288	NM_004454
ETV5	hsa-miR-219a-5p	84.1288	NM_004454
ETV5	hsa-miR-6766-3p	84.1288	NM_004454
ETV5	hsa-miR-3173-5p	83.9123	NM_004454
ETV5	hsa-miR-6799-3p	83.9123	NM_004454
ETV5	hsa-miR-1251-3p	83.5703	NM_004454
ETV5	hsa-miR-3065-5p	83.4485	NM_004454
ETV5	hsa-miR-6864-3p	83.2509	NM_004454
ETV5	hsa-miR-3672	83.2509	NM_004454
ETV5	hsa-miR-6835-5p	82.6573	NM_004454
ETV5	hsa-miR-548g-3p	82.577	NM_004454
ETV5	hsa-miR-7150	81.6314	NM_004454
ETV5	hsa-miR-544a	81.3538	NM_004454
ETV5	hsa-miR-664b-5p	81.3261	NM_004454
ETV5	hsa-miR-548an	81.2454	NM_004454
ETV5	hsa-miR-488-5p	80.4787	NM_004454

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Motifs and transcription factors (TFs) regulating ETV5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ETV5	transfac_pro__M03813	POU3F3 (directAnnotation).
ETV5	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
ETV5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ETV5	transfac_pro__M07397	ZNF148 (directAnnotation).
ETV5	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ETV5	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ETV5	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ETV5	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ETV5	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ETV5	transfac_pro__M01175	ZBTB7B (directAnnotation).
ETV5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ETV5	tfdimers__MD00151	CHURC1 (directAnnotation).
ETV5	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ETV5	transfac_pro__M01303	SP1 (directAnnotation).
ETV5	transfac_pro__M02089	E2F3 (directAnnotation).
ETV5	metacluster_3.14	WT1; WT1 (directAnnotation).
ETV5	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ETV5	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ETV5	transfac_pro__M07436	WT1 (directAnnotation).
ETV5	transfac_pro__M02281	SP1 (directAnnotation).
ETV5	transfac_public__M00491	PATZ1 (directAnnotation).
ETV5	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ETV5	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
ETV5	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ETV5	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
ETV5	transfac_pro__M06035	ZNF749 (directAnnotation).
ETV5	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ETV5	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ETV5	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
ETV5	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
ETV5	metacluster_52.11	ZNF184 (directAnnotation).
ETV5	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ETV5	jaspar__MA0502.2	NFYB (directAnnotation).
ETV5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ETV5	metacluster_7.13	ZFX (directAnnotation).
ETV5	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ETV5	cisbp__M00249	WT1 (directAnnotation).
ETV5	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ETV5	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	down	Malignant cells	GSE115251	NA
ETV5	metacluster_191.3	down	Malignant cells	GSE115251	NA
ETV5	metacluster_191.3	up	Malignant cells	GSE139386	NA
ETV5	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	up	Malignant cells	GSE139386	NA
ETV5	metacluster_166.4	up	Malignant cells	GSE139386	NA
ETV5	metacluster_138.2	up	Malignant cells	GSE139386	NA
ETV5	metacluster_191.3	up	Malignant cells	GSE186960	NA
ETV5	metacluster_166.4	up	Malignant cells	GSE186960	NA
ETV5	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	up	Malignant cells	GSE186960	NA
ETV5	metacluster_166.2	up	Malignant cells	GSE186960	NA
ETV5	metacluster_138.2	up	Malignant cells	GSE186960	NA
ETV5	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	up	Malignant cells	GSE186960	NA
ETV5	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	up	Malignant cells	GSE186960	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."