Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ETS2

Summary for ETS2

Gene information	Gene symbol	ETS2
	Ensembl ID	ENSG00000157557
	Entrez ID	2114
	Gene name	ETS proto-oncogene 2, transcription factor
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P15036

Top

Dataset with differentially expressed gene: ETS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.20679	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.31256	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.496525	3.14e-12
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.278841	3.36e-14
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.255069	5.88e-39
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.77892	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	Mono/Macro	-0.309313	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.266551	3.17e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.609691	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.559186	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.327761	1.37e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.27704	2.63e-08

Top

Expression of ETS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ETS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ETS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ETS2	hsa-miR-5688	95.9894	NM_001256295
ETS2	hsa-miR-495-3p	95.9894	NM_001256295
ETS2	hsa-miR-520d-5p	95.6463	NM_001256295
ETS2	hsa-miR-524-5p	95.6463	NM_001256295
ETS2	hsa-miR-374a-5p	91.5369	NM_001256295
ETS2	hsa-miR-6516-5p	90.3753	NM_001256295
ETS2	hsa-miR-6844	90.034	NM_001256295
ETS2	hsa-miR-6759-5p	89.3822	NM_001256295
ETS2	hsa-miR-548an	88.8062	NM_001256295
ETS2	hsa-miR-324-3p	88.5845	NM_001256295
ETS2	hsa-miR-374b-5p	88.2463	NM_001256295
ETS2	hsa-miR-98-3p	87.9255	NM_001256295
ETS2	hsa-let-7b-3p	87.9255	NM_001256295
ETS2	hsa-let-7a-3p	87.9255	NM_001256295
ETS2	hsa-let-7f-1-3p	87.9255	NM_001256295
ETS2	hsa-miR-203a-3p	87.889	NM_001256295
ETS2	hsa-miR-4753-5p	85.6709	NM_001256295
ETS2	hsa-miR-6737-3p	85.26	NM_001256295
ETS2	hsa-miR-7157-3p	85.26	NM_001256295
ETS2	hsa-miR-4668-3p	85.2127	NM_001256295
ETS2	hsa-miR-3690	84.1427	NM_001256295
ETS2	hsa-miR-5008-3p	83.6534	NM_001256295
ETS2	hsa-miR-146a-3p	83.5016	NM_001256295
ETS2	hsa-miR-4795-3p	83.2905	NM_001256295
ETS2	hsa-miR-4666a-3p	82.452	NM_001256295
ETS2	hsa-miR-944	82.2735	NM_001256295
ETS2	hsa-miR-5683	81.4965	NM_001256295
ETS2	hsa-miR-5010-3p	80.5324	NM_001256295

Page: 1

Top

Motifs and transcription factors (TFs) regulating ETS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ETS2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ETS2	cisbp__M07938	E2F1 (directAnnotation).
ETS2	jaspar__MA1483.2	ELF2 (directAnnotation).
ETS2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ETS2	cisbp__M08198	ELF1 (directAnnotation).
ETS2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ETS2	transfac_pro__M04748	GABPA (directAnnotation).
ETS2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
ETS2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ETS2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ETS2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
ETS2	transfac_pro__M04826	EP300 (directAnnotation).
ETS2	jaspar__MA1708.1	ETV7 (directAnnotation).
ETS2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ETS2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ETS2	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
ETS2	metacluster_32.24	ZNF287 (directAnnotation).
ETS2	metacluster_22.39	NFE2L2 (directAnnotation).
ETS2	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ETS2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ETS2	transfac_pro__M06173	ZNF85 (directAnnotation).
ETS2	transfac_pro__M06401	ZNF551 (directAnnotation).
ETS2	transfac_pro__M06157	ZNF445 (directAnnotation).
ETS2	transfac_pro__M06969	EBF4 (inferredBy_Orthology).
ETS2	metacluster_22.7	MAFK (directAnnotation).
ETS2	transfac_pro__M06325	ZNF585A (directAnnotation).
ETS2	transfac_pro__M06672	ZNF442 (directAnnotation).
ETS2	metacluster_22.8	MAF; MAFA; MAFF; MAFF; MAFG (directAnnotation).
ETS2	metacluster_26.9	ZNF354B (directAnnotation).
ETS2	transfac_pro__M06025	ZNF195 (directAnnotation).
ETS2	metacluster_130.9	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
ETS2	metacluster_22.2	MAFK (directAnnotation).
ETS2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ETS2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ETS2	transfac_pro__M01253	CNOT3 (directAnnotation).
ETS2	metacluster_7.13	ZFX (directAnnotation).
ETS2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ETS2	metacluster_175.1	ZNF283 (directAnnotation).
ETS2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ETS2	transfac_pro__M01973	PLAG1 (directAnnotation).
ETS2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ETS2	metacluster_198.3	ZFP64 (directAnnotation).
ETS2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ETS2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ETS2	metacluster_143.13	ZBTB7A (directAnnotation).
ETS2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
ETS2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ETS2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
ETS2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	down	Malignant cells	GSE131984_JQ1Pac	NA
ETS2	metacluster_191.3	down	Malignant cells	GSE131984_JQ1Pac	NA
ETS2	metacluster_138.2	down	Malignant cells	GSE131984_JQ1Pac	NA
ETS2	metacluster_35.5	down	Malignant cells	GSE131984_JQ1Pac	NA
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	down	Malignant cells	GSE131984_JQ1Pal	NA
ETS2	metacluster_191.3	down	Malignant cells	GSE131984_JQ1Pal	NA
ETS2	metacluster_138.2	down	Malignant cells	GSE131984_JQ1Pal	NA
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	up	Malignant cells	GSE138267	NA
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	up	Malignant cells	GSE153697	NA
ETS2	metacluster_191.3	up	Malignant cells	GSE153697	NA
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	up	cDCs	GSE169246_PacBlood	pre
ETS2	metacluster_191.3	up	cDCs	GSE169246_PacBlood	pre
ETS2	metacluster_191.3	down	Malignant cells	GSE186960	NA
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	down	Malignant cells	GSE186960	NA
ETS2	metacluster_138.2	down	Malignant cells	GSE186960	NA
ETS2	tfdimers__MD00044	down	Mono/Macro	GSE197268_Tisa-cel	post
ETS2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	down	Malignant cells	GSE199333	post
ETS2	metacluster_191.3	down	Malignant cells	GSE199333	post
ETS2	metacluster_35.2	down	Malignant cells	GSE199333	pre

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."