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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ESRP1

Summary for ESRP1

Gene information	Gene symbol	ESRP1
	Ensembl ID	ENSG00000104413
	Entrez ID	54845
	Gene name	epithelial splicing regulatory protein 1
	Synonyms	FLJ20171\|RBM35A
	Gene type	protein_coding
	UniProtAcc	Q6NXG1

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Dataset with differentially expressed gene: ESRP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.337674	1.46e-38
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.327565	0.00e+00

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Expression of ESRP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ESRP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ESRP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ESRP1	hsa-miR-3910	99.3866	NM_001122826
ESRP1	hsa-miR-4325	97.9669	NM_001034915
ESRP1	hsa-miR-338-5p	95.2105	NM_001122826
ESRP1	hsa-miR-92b-3p	94.0716	NM_001034915
ESRP1	hsa-miR-92a-3p	94.0716	NM_001034915
ESRP1	hsa-miR-32-5p	94.0716	NM_001034915
ESRP1	hsa-miR-6880-5p	93.4858	NM_001122826
ESRP1	hsa-miR-619-5p	93.2561	NM_001122826
ESRP1	hsa-miR-6506-5p	93.2561	NM_001122826
ESRP1	hsa-miR-548aj-3p	93.0677	NM_001034915
ESRP1	hsa-miR-548x-3p	93.0677	NM_001034915
ESRP1	hsa-miR-367-3p	92.4049	NM_001034915
ESRP1	hsa-miR-23b-3p	92.348	NM_001034915
ESRP1	hsa-miR-23a-3p	92.348	NM_001034915
ESRP1	hsa-miR-23c	92.348	NM_001034915
ESRP1	hsa-miR-548j-3p	91.8951	NM_001034915
ESRP1	hsa-miR-548am-3p	91.8951	NM_001034915
ESRP1	hsa-miR-548ae-3p	91.8951	NM_001034915
ESRP1	hsa-miR-548aq-3p	91.8951	NM_001034915
ESRP1	hsa-miR-548ah-3p	91.8951	NM_001034915
ESRP1	hsa-miR-6809-3p	91.7272	NM_001122826
ESRP1	hsa-miR-363-3p	91.5501	NM_001034915
ESRP1	hsa-miR-25-3p	91.5501	NM_001034915
ESRP1	hsa-miR-3125	90.5324	NM_001122826
ESRP1	hsa-miR-877-5p	89.1317	NM_001122826
ESRP1	hsa-miR-3916	88.8873	NM_001122826
ESRP1	hsa-miR-6859-5p	88.8873	NM_001122826
ESRP1	hsa-miR-4637	88.7944	NM_001122826
ESRP1	hsa-miR-3129-5p	88.3473	NM_001122826
ESRP1	hsa-miR-199a-3p	88.3473	NM_001122826
ESRP1	hsa-miR-199b-3p	88.3473	NM_001122826
ESRP1	hsa-miR-4685-3p	88.2049	NM_001122826
ESRP1	hsa-miR-4287	88.2049	NM_001122826
ESRP1	hsa-miR-3163	87.7862	NM_001034915
ESRP1	hsa-miR-1277-5p	87.0322	NM_001034915
ESRP1	hsa-miR-379-5p	86.6192	NM_001122826
ESRP1	hsa-miR-298	86.2534	NM_001122826
ESRP1	hsa-miR-6867-3p	85.3657	NM_001122826
ESRP1	hsa-miR-4795-3p	83.8742	NM_001034915
ESRP1	hsa-miR-302e	83.8468	NM_001034915
ESRP1	hsa-miR-520b-5p	83.6858	NM_001034915
ESRP1	hsa-miR-519a-2-5p	83.6858	NM_001034915
ESRP1	hsa-miR-4282	83.5229	NM_001122826
ESRP1	hsa-miR-498-5p	83.1354	NM_001034915
ESRP1	hsa-miR-3529-5p	82.7946	NM_001122826
ESRP1	hsa-miR-12119	80.988	NM_017697
ESRP1	hsa-miR-1283	80.226	NM_001034915
ESRP1	hsa-miR-3934-5p	80.1043	NM_001122826

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Motifs and transcription factors (TFs) regulating ESRP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ESRP1	transfac_pro__M07436	WT1 (directAnnotation).
ESRP1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ESRP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ESRP1	transfac_pro__M02089	E2F3 (directAnnotation).
ESRP1	transfac_pro__M07329	SP7 (directAnnotation).
ESRP1	transfac_pro__M01122	ZNF219 (directAnnotation).
ESRP1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ESRP1	metacluster_44.7	NKX3-2 (directAnnotation).
ESRP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ESRP1	transfac_pro__M08819	KLF2 (directAnnotation).
ESRP1	transfac_pro__M01175	ZBTB7B (directAnnotation).
ESRP1	cisbp__M00249	WT1 (directAnnotation).
ESRP1	transfac_pro__M01118	WT1 (directAnnotation).
ESRP1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ESRP1	transfac_pro__M01303	SP1 (directAnnotation).
ESRP1	transfac_pro__M01837	KLF11 (directAnnotation).
ESRP1	transfac_pro__M00716	ZBTB14 (directAnnotation).
ESRP1	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ESRP1	transfac_pro__M07397	ZNF148 (directAnnotation).
ESRP1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
ESRP1	transfac_pro__M01104	OVOL2 (directAnnotation).
ESRP1	transfac_pro__M00986	CHURC1 (directAnnotation).
ESRP1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ESRP1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."