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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ESCO1

Summary for ESCO1

Gene information	Gene symbol	ESCO1
	Ensembl ID	ENSG00000141446
	Entrez ID	114799
	Gene name	establishment of sister chromatid cohesion N-acetyltransferase 1
	Synonyms	EFO1\|ESO1\|KIAA1911
	Gene type	protein_coding
	UniProtAcc	Q5FWF5

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Dataset with differentially expressed gene: ESCO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.366765	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.291793	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.513399	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.395922	5.96e-37

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Expression of ESCO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ESCO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ESCO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ESCO1	hsa-miR-6515-3p	96.6557	NM_052911
ESCO1	hsa-miR-577	94.6435	NM_052911
ESCO1	hsa-miR-1305	94.1142	NM_052911
ESCO1	hsa-miR-6740-3p	94.0079	NM_052911
ESCO1	hsa-miR-3686	91.9189	NM_052911
ESCO1	hsa-miR-12119	91.6371	NM_052911
ESCO1	hsa-miR-4511	89.9661	NM_052911
ESCO1	hsa-miR-4795-3p	88.7335	NM_052911
ESCO1	hsa-miR-30a-5p	88.604	NM_052911
ESCO1	hsa-miR-30b-5p	88.604	NM_052911
ESCO1	hsa-miR-30c-5p	88.604	NM_052911
ESCO1	hsa-miR-30e-5p	88.604	NM_052911
ESCO1	hsa-miR-30d-5p	88.604	NM_052911
ESCO1	hsa-miR-587	87.0582	NM_052911
ESCO1	hsa-miR-4650-5p	84.8629	NM_052911
ESCO1	hsa-miR-6757-3p	83.854	NM_052911
ESCO1	hsa-miR-6841-3p	83.3946	NM_052911
ESCO1	hsa-miR-4774-5p	83.309	NM_052911
ESCO1	hsa-miR-3616-3p	81.5718	NM_052911

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Motifs and transcription factors (TFs) regulating ESCO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ESCO1	metacluster_135.11	NR2C2 (directAnnotation).
ESCO1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ESCO1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ESCO1	metacluster_7.13	ZFX (directAnnotation).
ESCO1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ESCO1	cisbp__M00968	MTF2 (directAnnotation).
ESCO1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ESCO1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ESCO1	cisbp__M00341	PAX6 (directAnnotation).
ESCO1	metacluster_198.3	ZFP64 (directAnnotation).
ESCO1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ESCO1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ESCO1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ESCO1	cisbp__M00788	ZFY (inferredBy_Orthology).
ESCO1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ESCO1	metacluster_175.1	ZNF283 (directAnnotation).
ESCO1	hdpi__ZNF304	ZNF304 (directAnnotation).
ESCO1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ESCO1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ESCO1	transfac_pro__M01199	TRIM28 (directAnnotation).
ESCO1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ESCO1	metacluster_151.2	ZNF23 (directAnnotation).
ESCO1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ESCO1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ESCO1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ESCO1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ESCO1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ESCO1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ESCO1	jaspar__MA0748.2	YY2 (directAnnotation).
ESCO1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ESCO1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ESCO1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ESCO1	transfac_pro__M00430	E2F1 (directAnnotation).
ESCO1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ESCO1	transfac_pro__M04893	TAF1 (directAnnotation).
ESCO1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ESCO1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ESCO1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
ESCO1	hdpi__HIP2	UBE2K (directAnnotation).
ESCO1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ESCO1	hdpi__TIMELESS	TIMELESS (directAnnotation).
ESCO1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ESCO1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ESCO1	metacluster_191.5	SPDEF (inferredBy_Orthology).
ESCO1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ESCO1	transfac_pro__M00938	E2F1 (directAnnotation).
ESCO1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
ESCO1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ESCO1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ESCO1	hdpi__RARA	RARA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."