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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ERO1A

Summary for ERO1A

Gene information	Gene symbol	ERO1A
	Ensembl ID	ENSG00000197930
	Entrez ID	30001
	Gene name	endoplasmic reticulum oxidoreductase 1 alpha
	Synonyms	ERO1-alpha\|Ero1alpha\|ERO1L
	Gene type	protein_coding
	UniProtAcc	Q96HE7

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Dataset with differentially expressed gene: ERO1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.71627	2.13e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.800686	2.30e-20
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.21314	0.00e+00

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Expression of ERO1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ERO1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ERO1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ERO1A	hsa-miR-3163	99.45	NM_014584
ERO1A	hsa-miR-12123	99.0054	NM_014584
ERO1A	hsa-miR-4282	94.1252	NM_014584
ERO1A	hsa-miR-6867-5p	93.7557	NM_014584
ERO1A	hsa-miR-1281	92.9614	NM_014584
ERO1A	hsa-miR-101-3p	90.8808	NM_014584
ERO1A	hsa-miR-4500	90.5441	NM_014584
ERO1A	hsa-miR-4477b	90.4667	NM_014584
ERO1A	hsa-miR-7161-5p	90.0536	NM_014584
ERO1A	hsa-miR-3686	89.6635	NM_014584
ERO1A	hsa-miR-548u	89.583	NM_014584
ERO1A	hsa-miR-144-3p	89.0096	NM_014584
ERO1A	hsa-let-7i-5p	88.8437	NM_014584
ERO1A	hsa-miR-98-5p	88.8437	NM_014584
ERO1A	hsa-let-7a-5p	88.8437	NM_014584
ERO1A	hsa-let-7g-5p	88.8437	NM_014584
ERO1A	hsa-let-7c-5p	88.8437	NM_014584
ERO1A	hsa-let-7b-5p	88.8437	NM_014584
ERO1A	hsa-let-7e-5p	88.8437	NM_014584
ERO1A	hsa-let-7f-5p	88.8437	NM_014584
ERO1A	hsa-miR-548az-5p	88.6976	NM_014584
ERO1A	hsa-miR-548t-5p	88.6976	NM_014584
ERO1A	hsa-miR-4458	87.9096	NM_014584
ERO1A	hsa-let-7d-5p	87.9096	NM_014584
ERO1A	hsa-miR-3074-5p	87.4364	NM_014584
ERO1A	hsa-miR-3606-5p	87.424	NM_014584
ERO1A	hsa-miR-410-3p	86.5736	NM_014584
ERO1A	hsa-miR-3162-5p	85.6062	NM_014584
ERO1A	hsa-miR-3908	85.0599	NM_014584
ERO1A	hsa-miR-3613-3p	84.5475	NM_014584
ERO1A	hsa-miR-6859-3p	84.0135	NM_014584
ERO1A	hsa-miR-190a-3p	83.5333	NM_014584
ERO1A	hsa-miR-590-3p	83.2302	NM_014584
ERO1A	hsa-miR-548l	82.5212	NM_014584
ERO1A	hsa-miR-5696	82.1336	NM_014584
ERO1A	hsa-miR-8485	82.0489	NM_014584
ERO1A	hsa-miR-7159-5p	81.8885	NM_014584
ERO1A	hsa-miR-548c-3p	81.3663	NM_014584

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Motifs and transcription factors (TFs) regulating ERO1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ERO1A	metacluster_135.11	NR2C2 (directAnnotation).
ERO1A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ERO1A	tfdimers__MD00038	TFAP2C (directAnnotation).
ERO1A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ERO1A	metacluster_7.13	ZFX (directAnnotation).
ERO1A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ERO1A	cisbp__M00968	MTF2 (directAnnotation).
ERO1A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ERO1A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ERO1A	cisbp__M00341	PAX6 (directAnnotation).
ERO1A	metacluster_198.3	ZFP64 (directAnnotation).
ERO1A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ERO1A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ERO1A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ERO1A	cisbp__M00788	ZFY (inferredBy_Orthology).
ERO1A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ERO1A	metacluster_175.1	ZNF283 (directAnnotation).
ERO1A	hdpi__ZNF304	ZNF304 (directAnnotation).
ERO1A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ERO1A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ERO1A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ERO1A	transfac_pro__M01199	TRIM28 (directAnnotation).
ERO1A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ERO1A	metacluster_151.2	ZNF23 (directAnnotation).
ERO1A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ERO1A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ERO1A	transfac_pro__M03806	ZBTB7C (directAnnotation).
ERO1A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ERO1A	metacluster_161.16	NKX3-2 (directAnnotation).
ERO1A	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
ERO1A	metacluster_51.12	PDX1 (directAnnotation).
ERO1A	hocomoco__PDX1_MOUSE.H11MO.0.B	PDX1 (inferredBy_Orthology).
ERO1A	taipale_tf_pairs__HOXA4_RTMATTAN_HT	HOXA4 (directAnnotation).
ERO1A	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
ERO1A	metacluster_51.15	HOXA5 (directAnnotation).
ERO1A	metacluster_51.19	HOXD4 (directAnnotation).
ERO1A	hdpi__TP73	TP73 (directAnnotation).
ERO1A	transfac_pro__M05976	ZNF223 (directAnnotation).
ERO1A	transfac_pro__M04950	EGR1 (directAnnotation).
ERO1A	transfac_pro__M02012	HIF1A (directAnnotation).
ERO1A	transfac_pro__M01249	EPAS1 (directAnnotation).
ERO1A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
ERO1A	metacluster_71.2	EPAS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."