Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ERF

Summary for ERF

Gene information	Gene symbol	ERF
	Ensembl ID	ENSG00000105722
	Entrez ID	2077
	Gene name	ETS2 repressor factor
	Synonyms	PE-2\|PE2
	Gene type	protein_coding
	UniProtAcc	P50548

Top

Dataset with differentially expressed gene: ERF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.372316	3.62e-39

Top

Expression of ERF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ERF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ERF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ERF	hsa-miR-4731-5p	97.7651	NM_001301035
ERF	hsa-miR-659-3p	96.9811	NM_001301035
ERF	hsa-miR-1207-5p	96.6858	NM_001301035
ERF	hsa-miR-1827	96.3474	NM_001301035
ERF	hsa-miR-4763-3p	95.7216	NM_001301035
ERF	hsa-miR-6742-5p	95.4002	NM_001308402
ERF	hsa-miR-6796-5p	94.5582	NM_001308402
ERF	hsa-miR-149-3p	94.0601	NM_001308402
ERF	hsa-let-7b-3p	93.7545	NM_001301035
ERF	hsa-let-7a-3p	93.7545	NM_001301035
ERF	hsa-miR-98-3p	93.7545	NM_001301035
ERF	hsa-let-7f-1-3p	93.7545	NM_001301035
ERF	hsa-miR-6785-5p	93.2158	NM_001308402
ERF	hsa-miR-4728-5p	93.2158	NM_001308402
ERF	hsa-miR-6883-5p	92.8743	NM_001308402
ERF	hsa-miR-6783-3p	91.9694	NM_001301035
ERF	hsa-miR-6715b-5p	91.917	NM_001301035
ERF	hsa-miR-4685-5p	91.032	NM_001308402
ERF	hsa-miR-6837-5p	91.032	NM_001308402
ERF	hsa-miR-6805-5p	90.8809	NM_001308402
ERF	hsa-miR-4690-5p	90.5201	NM_001301035
ERF	hsa-miR-3714	90.2757	NM_001301035
ERF	hsa-miR-7108-5p	89.5112	NM_001301035
ERF	hsa-miR-2052	88.8626	NM_001308402
ERF	hsa-miR-1343-3p	88.7324	NM_001301035
ERF	hsa-miR-4269	88.4242	NM_001301035
ERF	hsa-miR-4447	86.7726	NM_001308402
ERF	hsa-miR-548g-5p	85.3124	NM_001301035
ERF	hsa-miR-548f-5p	85.3124	NM_001301035
ERF	hsa-miR-548x-5p	85.3124	NM_001301035
ERF	hsa-miR-548aj-5p	85.3124	NM_001301035
ERF	hsa-miR-4789-5p	85.2675	NM_001301035
ERF	hsa-miR-1185-1-3p	85.2675	NM_001301035
ERF	hsa-miR-1185-2-3p	85.2675	NM_001301035
ERF	hsa-let-7f-2-3p	85.2675	NM_001301035
ERF	hsa-miR-2054	85.0447	NM_001308402
ERF	hsa-miR-3151-5p	84.1842	NM_001308402
ERF	hsa-miR-3671	84.0642	NM_001308402
ERF	hsa-miR-608	83.9659	NM_001301035
ERF	hsa-miR-2355-5p	83.6256	NM_001308402
ERF	hsa-miR-663b	83.6073	NM_001301035
ERF	hsa-miR-6742-3p	83.5362	NM_001301035
ERF	hsa-miR-491-5p	83.1449	NM_001308402
ERF	hsa-miR-4528	80.5921	NM_001308402

Page: 1

Top

Motifs and transcription factors (TFs) regulating ERF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ERF	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ERF	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ERF	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ERF	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ERF	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ERF	cisbp__M00249	WT1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ERF	metacluster_191.3	up	Malignant cells	GSE186960	NA
ERF	metacluster_138.2	up	Malignant cells	GSE186960	NA

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."