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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ERCC4

Summary for ERCC4

Gene information	Gene symbol	ERCC4
	Ensembl ID	ENSG00000175595
	Entrez ID	2072
	Gene name	ERCC excision repair 4, endonuclease catalytic subunit
	Synonyms	FANCQ\|RAD1\|XPF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ERCC4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.526341	5.78e-04

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Expression of ERCC4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ERCC4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ERCC4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ERCC4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ERCC4	hsa-miR-5000-5p	93.9573	NM_005236
ERCC4	hsa-miR-1277-5p	93.6631	NM_005236
ERCC4	hsa-miR-494-3p	93.643	NM_005236
ERCC4	hsa-miR-302e	92.972	NM_005236
ERCC4	hsa-miR-4760-3p	91.9397	NM_005236
ERCC4	hsa-miR-5692a	91.734	NM_005236
ERCC4	hsa-miR-4530	91.349	NM_005236
ERCC4	hsa-miR-590-3p	90.9025	NM_005236
ERCC4	hsa-miR-4493	90.4053	NM_005236
ERCC4	hsa-miR-551b-5p	90.2962	NM_005236
ERCC4	hsa-miR-1178-5p	89.9787	NM_005236
ERCC4	hsa-miR-3133	89.491	NM_005236
ERCC4	hsa-miR-4724-5p	88.6826	NM_005236
ERCC4	hsa-miR-548c-3p	88.6029	NM_005236
ERCC4	hsa-miR-3685	88.4961	NM_005236
ERCC4	hsa-miR-1252-3p	88.2371	NM_005236
ERCC4	hsa-miR-454-3p	87.9483	NM_005236
ERCC4	hsa-miR-519c-3p	87.8957	NM_005236
ERCC4	hsa-miR-519b-3p	87.8957	NM_005236
ERCC4	hsa-miR-519a-3p	87.8957	NM_005236
ERCC4	hsa-miR-301b-3p	87.7289	NM_005236
ERCC4	hsa-miR-301a-3p	87.7289	NM_005236
ERCC4	hsa-miR-130a-3p	87.7289	NM_005236
ERCC4	hsa-miR-130b-3p	87.7289	NM_005236
ERCC4	hsa-miR-3666	87.7289	NM_005236
ERCC4	hsa-miR-4295	87.7289	NM_005236
ERCC4	hsa-miR-4500	86.576	NM_005236
ERCC4	hsa-miR-4458	85.9515	NM_005236
ERCC4	hsa-let-7d-5p	85.9515	NM_005236
ERCC4	hsa-miR-520g-5p	85.333	NM_005236
ERCC4	hsa-miR-3613-3p	85.0131	NM_005236
ERCC4	hsa-miR-302a-3p	84.5961	NM_005236
ERCC4	hsa-miR-302c-3p	84.5961	NM_005236
ERCC4	hsa-miR-302d-3p	84.5961	NM_005236
ERCC4	hsa-miR-302b-3p	84.5961	NM_005236
ERCC4	hsa-miR-4536-5p	83.819	NM_005236
ERCC4	hsa-let-7i-5p	83.8131	NM_005236
ERCC4	hsa-let-7e-5p	83.8131	NM_005236
ERCC4	hsa-let-7c-5p	83.8131	NM_005236
ERCC4	hsa-let-7g-5p	83.8131	NM_005236
ERCC4	hsa-let-7b-5p	83.8131	NM_005236
ERCC4	hsa-let-7a-5p	83.8131	NM_005236
ERCC4	hsa-miR-98-5p	83.8131	NM_005236
ERCC4	hsa-let-7f-5p	83.8131	NM_005236
ERCC4	hsa-miR-3646	83.6729	NM_005236
ERCC4	hsa-miR-133a-5p	83.6307	NM_005236
ERCC4	hsa-miR-6885-3p	83.1943	NM_005236
ERCC4	hsa-miR-95-5p	82.523	NM_005236
ERCC4	hsa-miR-520e-3p	82.4632	NM_005236
ERCC4	hsa-miR-520c-3p	82.4632	NM_005236

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Motifs and transcription factors (TFs) regulating ERCC4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ERCC4	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."