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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ERAP1

Summary for ERAP1

Gene information	Gene symbol	ERAP1
	Ensembl ID	ENSG00000164307
	Entrez ID	51752
	Gene name	endoplasmic reticulum aminopeptidase 1
	Synonyms	A-LAP\|ARTS-1\|ERAAP1\|KIAA0525\|PILS-AP
	Gene type	protein_coding
	UniProtAcc	Q9NZ08

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Dataset with differentially expressed gene: ERAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.78879	1.56e-05

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Expression of ERAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ERAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ERAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ERAP1	hsa-miR-3646	99.1877	NM_016442
ERAP1	hsa-miR-7515	98.4193	NM_001040458
ERAP1	hsa-miR-95-5p	98.1911	NM_016442
ERAP1	hsa-miR-1253	97.4587	NM_001040458
ERAP1	hsa-miR-568	96.3763	NM_016442
ERAP1	hsa-miR-203a-3p	95.5322	NM_016442
ERAP1	hsa-miR-4482-3p	95.4327	NM_001040458
ERAP1	hsa-miR-3529-3p	93.9432	NM_001040458
ERAP1	hsa-miR-4422	93.4962	NM_016442
ERAP1	hsa-miR-106b-5p	92.9663	NM_016442
ERAP1	hsa-miR-20a-5p	92.9663	NM_016442
ERAP1	hsa-miR-3163	92.3634	NM_016442
ERAP1	hsa-miR-5692a	92.1808	NM_016442
ERAP1	hsa-miR-335-3p	91.9535	NM_016442
ERAP1	hsa-miR-330-3p	91.747	NM_016442
ERAP1	hsa-miR-4666a-3p	91.4653	NM_016442
ERAP1	hsa-miR-6074	91.2897	NM_001040458
ERAP1	hsa-miR-20b-5p	91.1334	NM_016442
ERAP1	hsa-miR-17-5p	91.1334	NM_016442
ERAP1	hsa-miR-106a-5p	91.1334	NM_016442
ERAP1	hsa-miR-4703-5p	91.0869	NM_016442
ERAP1	hsa-miR-4775	90.9448	NM_016442
ERAP1	hsa-miR-6864-5p	90.2686	NM_001040458
ERAP1	hsa-miR-6073	89.9343	NM_001040458
ERAP1	hsa-miR-4662a-3p	89.4369	NM_016442
ERAP1	hsa-miR-579-3p	89.3209	NM_016442
ERAP1	hsa-miR-93-5p	89.0537	NM_016442
ERAP1	hsa-miR-519d-3p	89.0537	NM_016442
ERAP1	hsa-miR-3688-5p	88.531	NM_001040458
ERAP1	hsa-miR-526b-3p	88.2814	NM_016442
ERAP1	hsa-miR-580-5p	88.2733	NM_016442
ERAP1	hsa-miR-1185-2-3p	87.7902	NM_016442
ERAP1	hsa-let-7f-2-3p	87.7902	NM_016442
ERAP1	hsa-miR-1185-1-3p	87.7902	NM_016442
ERAP1	hsa-miR-3942-5p	87.4328	NM_016442
ERAP1	hsa-miR-3144-3p	86.9843	NM_001040458
ERAP1	hsa-miR-664b-3p	86.2889	NM_016442
ERAP1	hsa-miR-6501-3p	86.1188	NM_016442
ERAP1	hsa-miR-30a-3p	85.6966	NM_001040458
ERAP1	hsa-miR-30d-3p	85.6966	NM_001040458
ERAP1	hsa-miR-30e-3p	85.6966	NM_001040458
ERAP1	hsa-miR-223-5p	85.4564	NM_001040458
ERAP1	hsa-miR-12117	85.3963	NM_016442
ERAP1	hsa-miR-5584-5p	85.1027	NM_001040458
ERAP1	hsa-miR-6770-5p	85.0648	NM_016442
ERAP1	hsa-miR-9983-3p	84.7388	NM_001040458
ERAP1	hsa-miR-205-3p	84.7286	NM_016442
ERAP1	hsa-miR-3065-5p	84.6461	NM_001040458
ERAP1	hsa-miR-16-2-3p	83.8571	NM_016442
ERAP1	hsa-miR-195-3p	83.8571	NM_016442

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Motifs and transcription factors (TFs) regulating ERAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ERAP1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ERAP1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ERAP1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ERAP1	transfac_pro__M04617	ZBTB7A (directAnnotation).
ERAP1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ERAP1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ERAP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ERAP1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ERAP1	transfac_pro__M07387	ZBTB7A (directAnnotation).
ERAP1	transfac_pro__M07436	WT1 (directAnnotation).
ERAP1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ERAP1	transfac_pro__M00716	ZBTB14 (directAnnotation).
ERAP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ERAP1	hdpi__HIP2	UBE2K (directAnnotation).
ERAP1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ERAP1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ERAP1	transfac_pro__M04893	TAF1 (directAnnotation).
ERAP1	transfac_pro__M03876	ZBTB33 (directAnnotation).
ERAP1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ERAP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ERAP1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ERAP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ERAP1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."