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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EPN2

Summary for EPN2

Gene information	Gene symbol	EPN2
	Ensembl ID	ENSG00000072134
	Entrez ID	22905
	Gene name	epsin 2
	Synonyms	EHB21\|KIAA1065
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EPN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.251804	2.62e-15
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.374972	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.328829	0.00e+00

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Expression of EPN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EPN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPN2	hsa-miR-340-5p	97.017	NM_001102664
EPN2	hsa-miR-548t-3p	96.7386	NM_001102664
EPN2	hsa-miR-548ap-3p	96.7386	NM_001102664
EPN2	hsa-miR-548aa	96.7386	NM_001102664
EPN2	hsa-miR-4662a-5p	96.336	NM_014964
EPN2	hsa-miR-519d-5p	95.1035	NM_001102664
EPN2	hsa-miR-1185-2-3p	93.4521	NM_014964
EPN2	hsa-miR-1185-1-3p	93.4521	NM_014964
EPN2	hsa-let-7f-2-3p	93.4521	NM_014964
EPN2	hsa-miR-7161-5p	93.2	NM_014964
EPN2	hsa-miR-548u	92.9064	NM_014964
EPN2	hsa-miR-8052	92.7844	NM_014964
EPN2	hsa-miR-548o-3p	91.8897	NM_014964
EPN2	hsa-miR-888-5p	91.8532	NM_001102664
EPN2	hsa-miR-372-5p	91.7556	NM_001102664
EPN2	hsa-miR-1323	91.7195	NM_014964
EPN2	hsa-miR-5692a	90.5502	NM_001102664
EPN2	hsa-miR-186-5p	90.3854	NM_001102664
EPN2	hsa-miR-148a-3p	90.2878	NM_001102664
EPN2	hsa-miR-152-3p	90.2878	NM_001102664
EPN2	hsa-miR-148b-3p	90.2878	NM_001102664
EPN2	hsa-miR-3157-5p	89.4531	NM_001102664
EPN2	hsa-miR-3199	88.9069	NM_014964
EPN2	hsa-miR-6875-3p	88.7302	NM_014964
EPN2	hsa-miR-9-3p	87.1599	NM_001102664
EPN2	hsa-miR-150-3p	87.08	NM_014964
EPN2	hsa-miR-5695	86.8929	NM_001102664
EPN2	hsa-miR-101-3p	86.8333	NM_014964
EPN2	hsa-miR-144-3p	86.8333	NM_014964
EPN2	hsa-miR-515-5p	86.7878	NM_001102664
EPN2	hsa-miR-519e-5p	86.7878	NM_001102664
EPN2	hsa-miR-4640-5p	86.4129	NM_014964
EPN2	hsa-miR-6885-3p	86.1404	NM_001102664
EPN2	hsa-miR-19a-3p	85.2319	NM_001102664
EPN2	hsa-miR-19b-3p	85.2319	NM_001102664
EPN2	hsa-miR-449a	85.2279	NM_001102664
EPN2	hsa-miR-34a-5p	85.2279	NM_001102664
EPN2	hsa-miR-4738-3p	84.3192	NM_014964
EPN2	hsa-miR-4726-5p	83.8348	NM_014964
EPN2	hsa-miR-3910	83.3291	NM_001102664
EPN2	hsa-miR-3663-5p	82.7043	NM_014964
EPN2	hsa-miR-7844-5p	82.5347	NM_014964
EPN2	hsa-miR-548an	82.2952	NM_001102664
EPN2	hsa-miR-548b-3p	82.0615	NM_014964
EPN2	hsa-miR-5004-5p	81.5741	NM_014964
EPN2	hsa-miR-4671-3p	81.5407	NM_001102664
EPN2	hsa-miR-4709-5p	81.2337	NM_001102664

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Motifs and transcription factors (TFs) regulating EPN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPN2	metacluster_7.13	ZFX (directAnnotation).
EPN2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
EPN2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
EPN2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EPN2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
EPN2	cisbp__M00249	WT1 (directAnnotation).
EPN2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
EPN2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
EPN2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
EPN2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
EPN2	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
EPN2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EPN2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
EPN2	metacluster_141.4	GLIS2 (directAnnotation).
EPN2	jaspar__MA0748.2	YY2 (directAnnotation).
EPN2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
EPN2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
EPN2	transfac_pro__M02089	E2F3 (directAnnotation).
EPN2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
EPN2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
EPN2	transfac_pro__M04817	ZBTB33 (directAnnotation).
EPN2	metacluster_143.13	ZBTB7A (directAnnotation).
EPN2	tfdimers__MD00483	ZBTB14 (directAnnotation).
EPN2	cisbp__M07938	E2F1 (directAnnotation).
EPN2	cisbp__M00968	MTF2 (directAnnotation).
EPN2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
EPN2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
EPN2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
EPN2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EPN2	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."