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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: EPHB4

Summary for EPHB4

Gene information	Gene symbol	EPHB4
	Ensembl ID	ENSG00000196411
	Entrez ID	2050
	Gene name	EPH receptor B4
	Synonyms	HTK\|Tyro11
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EPHB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.330858	1.85e-23
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.399036	8.95e-37

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Expression of EPHB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPHB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
EPHB4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating EPHB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPHB4	hsa-miR-98-3p	96.277	NM_004444
EPHB4	hsa-let-7b-3p	95.9144	NM_004444
EPHB4	hsa-let-7a-3p	95.9144	NM_004444
EPHB4	hsa-let-7f-1-3p	95.9144	NM_004444
EPHB4	hsa-miR-6756-3p	91.1784	NM_004444
EPHB4	hsa-miR-6825-5p	88.8796	NM_004444
EPHB4	hsa-miR-6777-5p	88.7638	NM_004444
EPHB4	hsa-miR-6889-5p	88.7638	NM_004444
EPHB4	hsa-miR-3127-3p	88.6092	NM_004444
EPHB4	hsa-miR-624-3p	87.016	NM_004444
EPHB4	hsa-miR-6887-3p	85.6297	NM_004444
EPHB4	hsa-miR-4527	84.7851	NM_004444
EPHB4	hsa-miR-6774-5p	81.0689	NM_004444
EPHB4	hsa-miR-1185-2-3p	80.1076	NM_004444
EPHB4	hsa-miR-4789-5p	80.1076	NM_004444
EPHB4	hsa-miR-1185-1-3p	80.1076	NM_004444
EPHB4	hsa-let-7f-2-3p	80.1076	NM_004444

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Motifs and transcription factors (TFs) regulating EPHB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPHB4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
EPHB4	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
EPHB4	metacluster_74.6	HNF1A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
EPHB4	"3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE"	DB07256	small molecule
EPHB4	"3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide"	DB07252	small molecule
EPHB4	"Dasatinib"	DB01254	small molecule
EPHB4	"Fostamatinib"	DB12010	small molecule
EPHB4	"N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE"	DB07251	small molecule
EPHB4	"N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE"	DB07250	small molecule
EPHB4	"N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine"	DB07253	small molecule
EPHB4	"N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE"	DB07255	small molecule
EPHB4	"N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine"	DB07249	small molecule
EPHB4	"N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE"	DB07254	small molecule
EPHB4	"Tesevatinib"	DB11973	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."