Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: EPHB2

Summary for EPHB2

Gene information	Gene symbol	EPHB2
	Ensembl ID	ENSG00000133216
	Entrez ID	2048
	Gene name	EPH receptor B2
	Synonyms	DRT\|EPHT3\|ERK\|Hek5\|Tyro5
	Gene type	protein_coding
	UniProtAcc	P29323

Top

Dataset with differentially expressed gene: EPHB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.358565	2.99e-38

Top

Expression of EPHB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to EPHB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating EPHB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPHB2	hsa-miR-15b-5p	99.4299	NM_001309192
EPHB2	hsa-miR-15a-5p	99.217	NM_001309192
EPHB2	hsa-miR-760	98.8091	NM_001309193
EPHB2	hsa-miR-195-5p	98.7561	NM_001309192
EPHB2	hsa-miR-16-5p	98.7561	NM_001309192
EPHB2	hsa-miR-4524b-5p	98.6506	NM_001309192
EPHB2	hsa-miR-4524a-5p	98.6506	NM_001309192
EPHB2	hsa-miR-6838-5p	98.1802	NM_001309192
EPHB2	hsa-miR-766-5p	97.9143	NM_001309192
EPHB2	hsa-miR-497-5p	97.7168	NM_001309192
EPHB2	hsa-miR-424-5p	97.7168	NM_001309192
EPHB2	hsa-miR-646	97.6096	NM_001309192
EPHB2	hsa-miR-23c	95.7032	NM_001309192
EPHB2	hsa-miR-23b-3p	95.4561	NM_001309192
EPHB2	hsa-miR-23a-3p	95.4561	NM_001309192
EPHB2	hsa-miR-6832-3p	95.4093	NM_001309192
EPHB2	hsa-miR-204-5p	94.0704	NM_001309192
EPHB2	hsa-miR-211-5p	94.0704	NM_001309192
EPHB2	hsa-miR-216a-3p	93.3822	NM_001309192
EPHB2	hsa-miR-128-3p	93.3822	NM_001309192
EPHB2	hsa-miR-6840-3p	92.8852	NM_001309192
EPHB2	hsa-miR-6734-3p	92.3682	NM_001309192
EPHB2	hsa-miR-3173-5p	91.1775	NM_001309192
EPHB2	hsa-miR-6830-3p	91.0823	NM_001309192
EPHB2	hsa-miR-4306	90.9877	NM_001309192
EPHB2	hsa-miR-150-5p	90.5331	NM_001309192
EPHB2	hsa-miR-3681-3p	90.4147	NM_001309192
EPHB2	hsa-miR-4492	89.109	NM_001309192
EPHB2	hsa-miR-6799-3p	88.7859	NM_001309192
EPHB2	hsa-miR-503-5p	88.1801	NM_001309192
EPHB2	hsa-miR-432-5p	88.1555	NM_001309192
EPHB2	hsa-miR-7114-5p	87.602	NM_001309193
EPHB2	hsa-miR-4254	85.8049	NM_001309193
EPHB2	hsa-miR-3921	85.4281	NM_001309192
EPHB2	hsa-miR-4653-5p	85.4281	NM_001309192
EPHB2	hsa-miR-4316	84.9146	NM_001309193
EPHB2	hsa-miR-4755-5p	84.5569	NM_001309192
EPHB2	hsa-miR-5006-3p	84.5569	NM_001309192
EPHB2	hsa-miR-4447	83.9032	NM_001309193
EPHB2	hsa-miR-486-3p	83.4241	NM_001309192
EPHB2	hsa-miR-1291	83.3102	NM_001309192
EPHB2	hsa-miR-6887-3p	83.1868	NM_001309192
EPHB2	hsa-miR-623	83.1739	NM_001309192
EPHB2	hsa-miR-7977	83.0648	NM_001309192
EPHB2	hsa-miR-660-3p	83.0014	NM_001309192
EPHB2	hsa-miR-4644	81.8756	NM_001309192
EPHB2	hsa-miR-185-5p	81.8756	NM_001309192
EPHB2	hsa-miR-8085	81.433	NM_001309192
EPHB2	hsa-miR-6881-3p	81.401	NM_001309192
EPHB2	hsa-miR-6727-3p	80.9899	NM_001309192

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating EPHB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPHB2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
EPHB2	"Fostamatinib"	DB12010	small molecule
EPHB2	"Oleandrin"	DB12843	small molecule
EPHB2	"Phosphoaminophosphonic Acid-Adenylate Ester"	DB04395	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."