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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: EPCAM

Summary for EPCAM

Gene information	Gene symbol	EPCAM
	Ensembl ID	ENSG00000119888
	Entrez ID	4072
	Gene name	epithelial cell adhesion molecule
	Synonyms	17-1A\|323/A3\|Ber-Ep4\|BerEp4\|CD326\|CO-17A\|EGP-2\|EGP34\|EGP40\|Ep-CAM\|ESA\|GA733-2\|HEA125\|KS1/4\|KSA\|Ly74\|M4S1\|MH99\|MIC18\|MK-1\|MOC-31\|MOC31\|TACST-1\|TACSTD1\|TROP1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EPCAM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.344877	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.548771	1.67e-20
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.371167	1.11e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.814402	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.466753	0.00e+00

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Expression of EPCAM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPCAM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EPCAM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPCAM	hsa-miR-4307	95.46	NM_002354
EPCAM	hsa-miR-33a-3p	92.105	NM_002354
EPCAM	hsa-miR-520d-5p	90.3775	NM_002354
EPCAM	hsa-miR-524-5p	90.3775	NM_002354
EPCAM	hsa-miR-4318	89.9921	NM_002354
EPCAM	hsa-miR-12136	88.0266	NM_002354
EPCAM	hsa-miR-466	87.3287	NM_002354
EPCAM	hsa-miR-4789-3p	86.4746	NM_002354
EPCAM	hsa-miR-4328	83.7811	NM_002354
EPCAM	hsa-miR-6839-5p	83.7244	NM_002354
EPCAM	hsa-miR-5692a	82.5155	NM_002354
EPCAM	hsa-miR-1290	82.3019	NM_002354
EPCAM	hsa-miR-590-3p	82.2629	NM_002354

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Motifs and transcription factors (TFs) regulating EPCAM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPCAM	transfac_pro__M06035	ZNF749 (directAnnotation).
EPCAM	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
EPCAM	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
EPCAM	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
EPCAM	transfac_pro__M06135	ZNF28 (directAnnotation).
EPCAM	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EPCAM	cisbp__M02645	ETS1 (directAnnotation).
EPCAM	metacluster_141.4	GLIS2 (directAnnotation).
EPCAM	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
EPCAM	tfdimers__MD00364	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
EPCAM	"Catumaxomab"	DB06607	biotech
EPCAM	"Hypromellose"	DB11075	small molecule
EPCAM	"ING-1"	DB05831	small molecule
EPCAM	"Oportuzumab monatox"	DB05319	biotech
EPCAM	"Technetium Tc-99m nofetumomab merpentan"	DB09336	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."