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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EPC2

Summary for EPC2

Gene information	Gene symbol	EPC2
	Ensembl ID	ENSG00000135999
	Entrez ID	26122
	Gene name	enhancer of polycomb homolog 2
	Synonyms	DKFZP566F2124
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EPC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.266459	1.77e-10

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Expression of EPC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EPC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPC2	hsa-miR-8076	99.7842	NM_015630
EPC2	hsa-miR-944	99.5723	NM_015630
EPC2	hsa-miR-194-5p	98.5042	NM_015630
EPC2	hsa-miR-106a-3p	98.2079	NM_015630
EPC2	hsa-miR-1297	98.0263	NM_015630
EPC2	hsa-miR-582-5p	96.8387	NM_015630
EPC2	hsa-miR-26a-5p	96.8171	NM_015630
EPC2	hsa-miR-26b-5p	96.8171	NM_015630
EPC2	hsa-miR-3682-3p	95.827	NM_015630
EPC2	hsa-miR-4465	95.7971	NM_015630
EPC2	hsa-miR-548l	95.5376	NM_015630
EPC2	hsa-miR-3121-3p	95.1429	NM_015630
EPC2	hsa-miR-519d-5p	94.9977	NM_015630
EPC2	hsa-miR-942-3p	94.8913	NM_015630
EPC2	hsa-miR-4698	94.4498	NM_015630
EPC2	hsa-miR-4262	93.7679	NM_015630
EPC2	hsa-miR-6810-3p	93.7378	NM_015630
EPC2	hsa-miR-6801-3p	93.2587	NM_015630
EPC2	hsa-miR-190b-5p	93.0102	NM_015630
EPC2	hsa-miR-190a-5p	93.0102	NM_015630
EPC2	hsa-miR-3688-3p	92.7434	NM_015630
EPC2	hsa-miR-181b-5p	92.5733	NM_015630
EPC2	hsa-miR-181c-5p	92.5733	NM_015630
EPC2	hsa-miR-181d-5p	92.5733	NM_015630
EPC2	hsa-miR-181a-5p	92.5733	NM_015630
EPC2	hsa-miR-1207-3p	92.2638	NM_015630
EPC2	hsa-miR-624-3p	91.5233	NM_015630
EPC2	hsa-miR-3680-3p	90.3928	NM_015630
EPC2	hsa-miR-548x-5p	90.1373	NM_015630
EPC2	hsa-miR-548aj-5p	90.1373	NM_015630
EPC2	hsa-miR-548f-5p	90.1373	NM_015630
EPC2	hsa-miR-548g-5p	90.1373	NM_015630
EPC2	hsa-miR-4735-5p	89.7118	NM_015630
EPC2	hsa-miR-507	89.536	NM_015630
EPC2	hsa-miR-454-3p	89.1477	NM_015630
EPC2	hsa-miR-6080	89.0031	NM_015630
EPC2	hsa-miR-557	88.9285	NM_015630
EPC2	hsa-miR-1468-3p	88.4035	NM_015630
EPC2	hsa-miR-137-3p	88.2283	NM_015630
EPC2	hsa-miR-4446-5p	87.9879	NM_015630
EPC2	hsa-miR-130b-3p	87.9253	NM_015630
EPC2	hsa-miR-301b-3p	87.9253	NM_015630
EPC2	hsa-miR-4295	87.9253	NM_015630
EPC2	hsa-miR-3666	87.9253	NM_015630
EPC2	hsa-miR-301a-3p	87.9253	NM_015630
EPC2	hsa-miR-130a-3p	87.9253	NM_015630
EPC2	hsa-miR-384	87.4877	NM_015630
EPC2	hsa-miR-6124	86.9248	NM_015630
EPC2	hsa-miR-323b-3p	85.9206	NM_015630
EPC2	hsa-miR-6847-3p	85.8345	NM_015630

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Motifs and transcription factors (TFs) regulating EPC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPC2	metacluster_135.11	NR2C2 (directAnnotation).
EPC2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
EPC2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
EPC2	metacluster_7.13	ZFX (directAnnotation).
EPC2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
EPC2	cisbp__M00968	MTF2 (directAnnotation).
EPC2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
EPC2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
EPC2	cisbp__M00341	PAX6 (directAnnotation).
EPC2	metacluster_198.3	ZFP64 (directAnnotation).
EPC2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
EPC2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
EPC2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
EPC2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
EPC2	cisbp__M00788	ZFY (inferredBy_Orthology).
EPC2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
EPC2	metacluster_175.1	ZNF283 (directAnnotation).
EPC2	hdpi__ZNF304	ZNF304 (directAnnotation).
EPC2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
EPC2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
EPC2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
EPC2	transfac_pro__M01199	TRIM28 (directAnnotation).
EPC2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
EPC2	metacluster_151.2	ZNF23 (directAnnotation).
EPC2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EPC2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EPC2	transfac_pro__M03806	ZBTB7C (directAnnotation).
EPC2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."