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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EPB41L4B

Summary for EPB41L4B

Gene information	Gene symbol	EPB41L4B
	Ensembl ID	ENSG00000095203
	Entrez ID	54566
	Gene name	erythrocyte membrane protein band 4.1 like 4B
	Synonyms	EHM2\|LULU2
	Gene type	protein_coding
	UniProtAcc	Q9H329

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Dataset with differentially expressed gene: EPB41L4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.370301	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.4813	0.00e+00

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Expression of EPB41L4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPB41L4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EPB41L4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPB41L4B	hsa-miR-873-5p	95.8465	NM_018424
EPB41L4B	hsa-miR-4427	94.7084	NM_019114
EPB41L4B	hsa-miR-3646	93.2351	NM_019114
EPB41L4B	hsa-miR-4724-3p	91.2078	NM_018424
EPB41L4B	hsa-miR-551b-5p	90.7092	NM_019114
EPB41L4B	hsa-miR-7161-5p	89.7985	NM_019114
EPB41L4B	hsa-miR-4282	88.5883	NM_019114
EPB41L4B	hsa-miR-6730-3p	88.4314	NM_019114
EPB41L4B	hsa-miR-9851-3p	88.2894	NM_019114
EPB41L4B	hsa-miR-5094	88.0317	NM_019114
EPB41L4B	hsa-miR-548u	87.921	NM_019114
EPB41L4B	hsa-miR-6792-5p	87.8026	NM_018424
EPB41L4B	hsa-miR-593-5p	86.2457	NM_019114
EPB41L4B	hsa-miR-8063	86.0175	NM_019114
EPB41L4B	hsa-miR-3662	85.9487	NM_018424
EPB41L4B	hsa-miR-548c-3p	84.8024	NM_019114
EPB41L4B	hsa-miR-3074-5p	84.1716	NM_019114
EPB41L4B	hsa-miR-383-3p	84.0331	NM_019114
EPB41L4B	hsa-miR-548p	83.3179	NM_019114
EPB41L4B	hsa-miR-5688	83.1681	NM_019114
EPB41L4B	hsa-miR-6077	82.8719	NM_018424
EPB41L4B	hsa-miR-410-3p	82.705	NM_018424
EPB41L4B	hsa-miR-620	82.6852	NM_019114
EPB41L4B	hsa-miR-1270	82.6852	NM_019114
EPB41L4B	hsa-miR-503-3p	82.5944	NM_018424
EPB41L4B	hsa-miR-6718-5p	82.5112	NM_019114
EPB41L4B	hsa-miR-203b-5p	82.5112	NM_019114
EPB41L4B	hsa-miR-625-5p	81.9848	NM_018424
EPB41L4B	hsa-miR-589-3p	81.6295	NM_018424
EPB41L4B	hsa-miR-3162-5p	80.9335	NM_018424
EPB41L4B	hsa-miR-16-5p	80.9098	NM_019114
EPB41L4B	hsa-miR-195-5p	80.9098	NM_019114
EPB41L4B	hsa-miR-15a-5p	80.9098	NM_019114
EPB41L4B	hsa-miR-15b-5p	80.9098	NM_019114
EPB41L4B	hsa-miR-186-5p	80.2001	NM_019114
EPB41L4B	hsa-miR-205-3p	80.1054	NM_019114
EPB41L4B	hsa-miR-3198	80.0739	NM_018424
EPB41L4B	hsa-miR-4309	80.0739	NM_018424

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Motifs and transcription factors (TFs) regulating EPB41L4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPB41L4B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EPB41L4B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
EPB41L4B	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
EPB41L4B	transfac_pro__M02089	E2F3 (directAnnotation).
EPB41L4B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
EPB41L4B	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
EPB41L4B	transfac_pro__M04817	ZBTB33 (directAnnotation).
EPB41L4B	tfdimers__MD00483	ZBTB14 (directAnnotation).
EPB41L4B	cisbp__M07938	E2F1 (directAnnotation).
EPB41L4B	cisbp__M00968	MTF2 (directAnnotation).
EPB41L4B	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
EPB41L4B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
EPB41L4B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EPB41L4B	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."