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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EPB41L1

Summary for EPB41L1

Gene information	Gene symbol	EPB41L1
	Ensembl ID	ENSG00000088367
	Entrez ID	2036
	Gene name	erythrocyte membrane protein band 4.1 like 1
	Synonyms	4.1N\|KIAA0338
	Gene type	protein_coding
	UniProtAcc	Q9H4G0

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Dataset with differentially expressed gene: EPB41L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.324557	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.413029	0.00e+00

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Expression of EPB41L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EPB41L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EPB41L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EPB41L1	hsa-miR-7152-5p	99.5976	NM_001258330
EPB41L1	hsa-miR-5011-5p	99.5611	NM_001258329
EPB41L1	hsa-miR-3074-5p	97.4269	NM_001258329
EPB41L1	hsa-miR-3191-3p	96.8816	NM_001258329
EPB41L1	hsa-miR-6870-5p	96.2622	NM_001258330
EPB41L1	hsa-miR-190a-3p	95.9482	NM_001258330
EPB41L1	hsa-miR-3140-3p	95.4121	NM_001258329
EPB41L1	hsa-miR-5698	94.6436	NM_001258330
EPB41L1	hsa-miR-4723-5p	94.6436	NM_001258330
EPB41L1	hsa-miR-7111-5p	94.6436	NM_001258330
EPB41L1	hsa-miR-4288	94.0971	NM_001258330
EPB41L1	hsa-miR-18a-5p	93.5924	NM_001258329
EPB41L1	hsa-miR-18b-5p	93.5924	NM_001258329
EPB41L1	hsa-miR-632	93.5529	NM_001258330
EPB41L1	hsa-miR-6794-5p	93.3326	NM_001258330
EPB41L1	hsa-miR-4735-3p	93.1534	NM_001258329
EPB41L1	hsa-miR-4716-3p	93.0893	NM_001258330
EPB41L1	hsa-miR-3121-5p	92.6367	NM_001258329
EPB41L1	hsa-miR-6825-5p	92.53	NM_001258330
EPB41L1	hsa-miR-4306	91.663	NM_001258330
EPB41L1	hsa-miR-6124	90.4471	NM_001258330
EPB41L1	hsa-miR-1248	90.2943	NM_001258329
EPB41L1	hsa-miR-527	90.0698	NM_001258329
EPB41L1	hsa-miR-518a-5p	90.0698	NM_001258329
EPB41L1	hsa-miR-6895-3p	89.7006	NM_001258329
EPB41L1	hsa-miR-3127-3p	89.1876	NM_001258329
EPB41L1	hsa-miR-6756-3p	89.1876	NM_001258329
EPB41L1	hsa-miR-6764-3p	88.482	NM_001258329
EPB41L1	hsa-miR-518c-5p	88.482	NM_001258329
EPB41L1	hsa-miR-6824-3p	88.482	NM_001258329
EPB41L1	hsa-miR-330-5p	88.482	NM_001258329
EPB41L1	hsa-miR-4640-5p	88.4585	NM_001258330
EPB41L1	hsa-miR-4705	88.1729	NM_001258329
EPB41L1	hsa-miR-5008-5p	88.0249	NM_001258329
EPB41L1	hsa-miR-636	87.827	NM_001258330
EPB41L1	hsa-miR-5193	87.6162	NM_001258329
EPB41L1	hsa-miR-3191-5p	87.1445	NM_001258329
EPB41L1	hsa-miR-4726-5p	86.5948	NM_001258330
EPB41L1	hsa-miR-3667-5p	86.2367	NM_001258330
EPB41L1	hsa-miR-6847-3p	86.1617	NM_001258329
EPB41L1	hsa-miR-326	85.9913	NM_001258329
EPB41L1	hsa-miR-4276	85.8674	NM_001258330
EPB41L1	hsa-miR-300	85.7882	NM_001258330
EPB41L1	hsa-miR-381-3p	85.7882	NM_001258330
EPB41L1	hsa-miR-216a-3p	85.4128	NM_001258329
EPB41L1	hsa-miR-128-3p	85.4128	NM_001258329
EPB41L1	hsa-miR-3688-5p	85.2458	NM_001258330
EPB41L1	hsa-miR-3675-3p	84.9805	NM_001258330
EPB41L1	hsa-miR-891a-3p	83.8351	NM_001258330
EPB41L1	hsa-miR-4455	83.8241	NM_001258330

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Motifs and transcription factors (TFs) regulating EPB41L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EPB41L1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
EPB41L1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
EPB41L1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
EPB41L1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
EPB41L1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
EPB41L1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
EPB41L1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
EPB41L1	cisbp__M08198	ELF1 (directAnnotation).
EPB41L1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
EPB41L1	jaspar__MA1957.1	ELK1 (directAnnotation).
EPB41L1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
EPB41L1	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."