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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ENTPD4

Summary for ENTPD4

Gene information	Gene symbol	ENTPD4
	Ensembl ID	ENSG00000197217
	Entrez ID	9583
	Gene name	ectonucleoside triphosphate diphosphohydrolase 4
	Synonyms	KIAA0392\|LALP70\|LAP70\|LYSAL1\|NTPDase-4\|UDPase
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ENTPD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.265945	0.00e+00

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Expression of ENTPD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ENTPD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ENTPD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ENTPD4	hsa-miR-4649-3p	95.6512	NM_001128930
ENTPD4	hsa-miR-320d	93.3225	NM_001128930
ENTPD4	hsa-miR-4429	93.3225	NM_001128930
ENTPD4	hsa-miR-320c	93.3225	NM_001128930
ENTPD4	hsa-miR-320a-3p	93.3225	NM_001128930
ENTPD4	hsa-miR-320b	93.3225	NM_001128930
ENTPD4	hsa-miR-4448	92.8849	NM_001128930
ENTPD4	hsa-miR-7152-5p	92.7453	NM_001128930
ENTPD4	hsa-miR-544b	91.0298	NM_001128930
ENTPD4	hsa-miR-106b-5p	90.3715	NM_001128930
ENTPD4	hsa-miR-526b-3p	90.3715	NM_001128930
ENTPD4	hsa-miR-106a-5p	90.3715	NM_001128930
ENTPD4	hsa-miR-20a-5p	90.3715	NM_001128930
ENTPD4	hsa-miR-4799-5p	90.2611	NM_001128930
ENTPD4	hsa-miR-659-3p	89.9075	NM_001128930
ENTPD4	hsa-miR-520g-3p	89.6314	NM_001128930
ENTPD4	hsa-miR-520h	89.6314	NM_001128930
ENTPD4	hsa-miR-1827	87.4423	NM_001128930
ENTPD4	hsa-miR-20b-5p	87.1327	NM_001128930
ENTPD4	hsa-miR-519d-3p	87.1327	NM_001128930
ENTPD4	hsa-miR-17-5p	87.1327	NM_001128930
ENTPD4	hsa-miR-93-5p	87.1327	NM_001128930
ENTPD4	hsa-miR-583	86.8828	NM_001128930
ENTPD4	hsa-miR-545-3p	85.6647	NM_001128930
ENTPD4	hsa-miR-520e-5p	85.4257	NM_001128930
ENTPD4	hsa-miR-519c-3p	84.5842	NM_001128930
ENTPD4	hsa-miR-519a-3p	84.5842	NM_001128930
ENTPD4	hsa-miR-519b-3p	84.5842	NM_001128930
ENTPD4	hsa-miR-4252	84.4689	NM_001128930
ENTPD4	hsa-miR-5681a	83.2954	NM_001128930
ENTPD4	hsa-miR-224-3p	82.7075	NM_001128930
ENTPD4	hsa-miR-522-3p	82.7075	NM_001128930
ENTPD4	hsa-miR-135a-5p	82.189	NM_001128930
ENTPD4	hsa-miR-135b-5p	82.189	NM_001128930
ENTPD4	hsa-miR-6809-3p	81.5878	NM_001128930
ENTPD4	hsa-miR-4692	81.2364	NM_001128930
ENTPD4	hsa-miR-3119	81.1873	NM_001128930
ENTPD4	hsa-miR-6739-5p	80.3375	NM_001128930
ENTPD4	hsa-miR-6733-5p	80.3375	NM_001128930
ENTPD4	hsa-miR-3153	80.3375	NM_001128930
ENTPD4	hsa-miR-4319	80.0888	NM_001128930

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Motifs and transcription factors (TFs) regulating ENTPD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ENTPD4	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ENTPD4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ENTPD4	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ENTPD4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ENTPD4	metacluster_151.2	ZNF23 (directAnnotation).
ENTPD4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ENTPD4	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ENTPD4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ENTPD4	transfac_pro__M01199	TRIM28 (directAnnotation).
ENTPD4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ENTPD4	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ENTPD4	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ENTPD4	transfac_pro__M01253	CNOT3 (directAnnotation).
ENTPD4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ENTPD4	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ENTPD4	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ENTPD4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ENTPD4	cisbp__M00968	MTF2 (directAnnotation).
ENTPD4	metacluster_7.13	ZFX (directAnnotation).
ENTPD4	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ENTPD4	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ENTPD4	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ENTPD4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ENTPD4	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ENTPD4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ENTPD4	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ENTPD4	transfac_pro__M07310	SP5 (directAnnotation).
ENTPD4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ENTPD4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ENTPD4	transfac_pro__M00938	E2F1 (directAnnotation).
ENTPD4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ENTPD4	transfac_pro__M04893	TAF1 (directAnnotation).
ENTPD4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ENTPD4	transfac_pro__M04817	ZBTB33 (directAnnotation).
ENTPD4	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ENTPD4	transfac_pro__M12697	ZNF142 (directAnnotation).
ENTPD4	metacluster_175.1	ZNF283 (directAnnotation).
ENTPD4	cisbp__M00788	ZFY (inferredBy_Orthology).
ENTPD4	tfdimers__MD00364	WT1 (directAnnotation).
ENTPD4	hdpi__ZNF304	ZNF304 (directAnnotation).
ENTPD4	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ENTPD4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ENTPD4	transfac_pro__M04916	TAF1 (directAnnotation).
ENTPD4	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ENTPD4	transfac_pro__M01973	PLAG1 (directAnnotation).
ENTPD4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ENTPD4	tfdimers__MD00483	ZBTB14 (directAnnotation).
ENTPD4	metacluster_198.3	ZFP64 (directAnnotation).
ENTPD4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ENTPD4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."