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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ENTPD1

Summary for ENTPD1

Gene information	Gene symbol	ENTPD1
	Ensembl ID	ENSG00000138185
	Entrez ID	953
	Gene name	ectonucleoside triphosphate diphosphohydrolase 1
	Synonyms	ATPDase\|CD39\|NTPDase-1\|SPG64
	Gene type	protein_coding
	UniProtAcc	P49961

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Dataset with differentially expressed gene: ENTPD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.420764	5.07e-21
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.573952	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.686814	8.19e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.359796	6.02e-25

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Expression of ENTPD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ENTPD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ENTPD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ENTPD1	hsa-miR-1304-5p	95.7573	NM_001164179
ENTPD1	hsa-miR-205-3p	95.0943	NM_001164179
ENTPD1	hsa-miR-4677-5p	94.851	NM_001164179
ENTPD1	hsa-miR-4428	92.6715	NM_001164179
ENTPD1	hsa-miR-4652-3p	91.5767	NM_001164179
ENTPD1	hsa-miR-3202	91.0781	NM_001164179
ENTPD1	hsa-miR-153-5p	91.0372	NM_001098175
ENTPD1	hsa-miR-4477a	90.9833	NM_001164179
ENTPD1	hsa-miR-6833-3p	90.6199	NM_001164179
ENTPD1	hsa-miR-758-3p	90.0294	NM_001164179
ENTPD1	hsa-miR-1537-5p	89.5567	NM_001164179
ENTPD1	hsa-miR-4659a-3p	89.2033	NM_001164179
ENTPD1	hsa-miR-4659b-3p	89.2033	NM_001164179
ENTPD1	hsa-miR-518a-5p	89.1401	NM_001164179
ENTPD1	hsa-miR-527	89.1401	NM_001164179
ENTPD1	hsa-miR-4768-5p	89.0882	NM_001164179
ENTPD1	hsa-miR-3119	89.0209	NM_001098175
ENTPD1	hsa-miR-450b-5p	88.9622	NM_001164179
ENTPD1	hsa-miR-3682-3p	88.6154	NM_001320916
ENTPD1	hsa-miR-7112-3p	88.3317	NM_001320916
ENTPD1	hsa-miR-548l	86.6865	NM_001320916
ENTPD1	hsa-miR-4794	86.5014	NM_001320916
ENTPD1	hsa-miR-664a-5p	86.5014	NM_001320916
ENTPD1	hsa-miR-6765-5p	86.4428	NM_001164179
ENTPD1	hsa-miR-4503	85.944	NM_001320916
ENTPD1	hsa-miR-4764-5p	85.815	NM_001320916
ENTPD1	hsa-miR-4470	85.581	NM_001164179
ENTPD1	hsa-miR-4517	85.4984	NM_001164179
ENTPD1	hsa-miR-545-5p	85.3743	NM_001164179
ENTPD1	hsa-miR-451b	85.3404	NM_001164179
ENTPD1	hsa-miR-223-5p	85.0701	NM_001320916
ENTPD1	hsa-miR-6756-5p	84.8097	NM_001164179
ENTPD1	hsa-miR-6766-5p	84.8097	NM_001164179
ENTPD1	hsa-miR-6512-3p	84.6184	NM_001164179
ENTPD1	hsa-miR-590-3p	84.18	NM_001164179
ENTPD1	hsa-miR-548ar-3p	84.0523	NM_001164179
ENTPD1	hsa-miR-583	83.7971	NM_001320916
ENTPD1	hsa-miR-3148	83.2166	NM_001164179
ENTPD1	hsa-miR-6715b-3p	83.1924	NM_001164179
ENTPD1	hsa-miR-6720-5p	82.9032	NM_001164179
ENTPD1	hsa-miR-6778-3p	82.2331	NM_001164179
ENTPD1	hsa-miR-4305	82.1635	NM_001164179
ENTPD1	hsa-miR-7110-3p	82.0882	NM_001164179
ENTPD1	hsa-miR-8076	82.0809	NM_001164179
ENTPD1	hsa-miR-6799-5p	81.6655	NM_001164179
ENTPD1	hsa-miR-4495	81.1871	NM_001164179
ENTPD1	hsa-miR-562	80.9157	NM_001164179
ENTPD1	hsa-miR-548a-3p	80.8703	NM_001164179
ENTPD1	hsa-miR-4722-5p	80.7851	NM_001164179
ENTPD1	hsa-miR-6858-3p	80.7654	NM_001098175

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Motifs and transcription factors (TFs) regulating ENTPD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ENTPD1	transfac_pro__M07448	ZBED1 (directAnnotation).
ENTPD1	transfac_pro__M05481	ZNF202 (directAnnotation).
ENTPD1	jaspar__MA1952.1	FOXJ2 (directAnnotation).
ENTPD1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ENTPD1	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
ENTPD1	transfac_pro__M06282	ZSCAN10 (inferredBy_Orthology).
ENTPD1	transfac_pro__M05647	ZNF875 (directAnnotation).
ENTPD1	metacluster_75.11	SCRT1; SCRT2 (directAnnotation).
ENTPD1	metacluster_75.12	SCRT1; SCRT2 (directAnnotation).
ENTPD1	transfac_pro__M05942	ZNF700 (directAnnotation).
ENTPD1	metacluster_75.7	SCRT1; SCRT1; SCRT1; SCRT2 (directAnnotation).
ENTPD1	transfac_pro__M06032	ZNF727 (directAnnotation).
ENTPD1	metacluster_75.9	SCRT2; SCRT2 (directAnnotation). SCRT1; SCRT1; SCRT1; SCRT1; SCRT2; SCRT2; SCRT2; SCRT2 (inferredBy_Orthology).
ENTPD1	taipale_tf_pairs__TFAP4_DLX3_NNCAGCTGNNNNTAATKR_HT	DLX3; TFAP4 (directAnnotation).
ENTPD1	transfac_pro__M00731	RUNX2 (directAnnotation).
ENTPD1	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
ENTPD1	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
ENTPD1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
ENTPD1	transfac_pro__M06013	ZFP69B (directAnnotation).
ENTPD1	tfdimers__MD00033	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM; YY1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."