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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ENOSF1

Summary for ENOSF1

Gene information	Gene symbol	ENOSF1
	Ensembl ID	ENSG00000132199
	Entrez ID	55556
	Gene name	enolase superfamily member 1
	Synonyms	FUCD\|HSRTSBETA\|rTS\|TYMSAS
	Gene type	protein_coding
	UniProtAcc	Q7L5Y1

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Dataset with differentially expressed gene: ENOSF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.263363	0.00e+00

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Expression of ENOSF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ENOSF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ENOSF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ENOSF1	hsa-miR-4477b	91.9683	NM_001318760
ENOSF1	hsa-miR-7160-5p	89.7827	NM_017512
ENOSF1	hsa-miR-7856-5p	88.8801	NM_017512
ENOSF1	hsa-miR-3667-3p	87.6535	NM_017512
ENOSF1	hsa-miR-4687-3p	87.5967	NM_202758
ENOSF1	hsa-miR-4999-5p	86.869	NM_017512
ENOSF1	hsa-miR-4775	86.033	NM_017512
ENOSF1	hsa-miR-511-3p	85.6566	NM_017512
ENOSF1	hsa-miR-4277	85.4626	NM_017512
ENOSF1	hsa-miR-208a-5p	85.0882	NM_017512
ENOSF1	hsa-miR-208b-5p	85.0882	NM_017512
ENOSF1	hsa-miR-6820-3p	84.9773	NM_202758
ENOSF1	hsa-miR-3164	84.9773	NM_202758
ENOSF1	hsa-miR-582-5p	84.9627	NM_001318760
ENOSF1	hsa-miR-1297	84.6386	NM_017512
ENOSF1	hsa-miR-889-5p	83.1127	NM_202758
ENOSF1	hsa-miR-651-5p	83.021	NM_017512
ENOSF1	hsa-miR-3150b-3p	82.4262	NM_017512
ENOSF1	hsa-miR-4784	82.4262	NM_017512
ENOSF1	hsa-miR-9903	81.6712	NM_017512
ENOSF1	hsa-miR-541-3p	81.643	NM_202758
ENOSF1	hsa-miR-654-5p	81.643	NM_202758
ENOSF1	hsa-miR-6505-3p	80.9399	NM_017512
ENOSF1	hsa-miR-767-3p	80.6212	NM_017512
ENOSF1	hsa-miR-541-5p	80.2261	NM_001318760
ENOSF1	hsa-miR-3690	80.0504	NM_001318760

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Motifs and transcription factors (TFs) regulating ENOSF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ENOSF1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ENOSF1	hdpi__TP73	TP73 (directAnnotation).
ENOSF1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ENOSF1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ENOSF1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."