Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ENC1

Summary for ENC1

Gene information	Gene symbol	ENC1
	Ensembl ID	ENSG00000171617
	Entrez ID	8507
	Gene name	ectodermal-neural cortex 1
	Synonyms	ENC-1\|KLHL37\|NRPB\|PIG10\|TP53I10
	Gene type	protein_coding
	UniProtAcc	O14682

Top

Dataset with differentially expressed gene: ENC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.440611	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.66613	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.500703	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.754079	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.682872	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.584958	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.251751	2.75e-17

Top

Expression of ENC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ENC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ENC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ENC1	hsa-miR-3121-3p	98.7654	NM_001256574
ENC1	hsa-miR-3944-5p	98.0388	NM_001256574
ENC1	hsa-miR-3120-3p	95.932	NM_001256574
ENC1	hsa-miR-4289	94.6851	NM_001256574
ENC1	hsa-miR-5692a	94.2522	NM_001256574
ENC1	hsa-miR-6515-3p	93.3919	NM_001256574
ENC1	hsa-miR-548p	92.4125	NM_001256574
ENC1	hsa-miR-3675-3p	92.0981	NM_001256576
ENC1	hsa-miR-4306	91.8573	NM_001256576
ENC1	hsa-miR-513a-5p	91.2938	NM_001256576
ENC1	hsa-miR-4698	90.7637	NM_001256574
ENC1	hsa-miR-185-5p	90.7465	NM_001256576
ENC1	hsa-miR-4644	90.7465	NM_001256576
ENC1	hsa-miR-6833-3p	89.3916	NM_001256576
ENC1	hsa-miR-6868-3p	89.2	NM_001256574
ENC1	hsa-miR-219a-2-3p	89.0201	NM_001256574
ENC1	hsa-miR-133b	88.9953	NM_001256574
ENC1	hsa-miR-133a-3p	88.9953	NM_001256574
ENC1	hsa-miR-539-5p	88.676	NM_001256574
ENC1	hsa-miR-6511b-5p	88.4648	NM_001256574
ENC1	hsa-miR-6811-5p	88.4648	NM_001256574
ENC1	hsa-miR-6809-3p	88.4249	NM_001256576
ENC1	hsa-miR-4328	88.3061	NM_001256576
ENC1	hsa-miR-19a-3p	88.2925	NM_001256574
ENC1	hsa-miR-19b-3p	88.2925	NM_001256574
ENC1	hsa-miR-3158-5p	88.2855	NM_001256574
ENC1	hsa-miR-4639-3p	87.8842	NM_001256576
ENC1	hsa-miR-205-5p	87.3911	NM_001256574
ENC1	hsa-miR-3184-5p	86.9751	NM_001256576
ENC1	hsa-miR-423-5p	86.9751	NM_001256576
ENC1	hsa-miR-216b-5p	86.8972	NM_001256576
ENC1	hsa-miR-4768-5p	86.7257	NM_001256576
ENC1	hsa-miR-3680-3p	86.1212	NM_001256574
ENC1	hsa-miR-23a-3p	86.1116	NM_001256574
ENC1	hsa-miR-23c	86.1116	NM_001256574
ENC1	hsa-miR-23b-3p	86.1116	NM_001256574
ENC1	hsa-miR-3977	85.7445	NM_001256576
ENC1	hsa-miR-548av-5p	85.6618	NM_001256576
ENC1	hsa-miR-548k	85.6618	NM_001256576
ENC1	hsa-miR-6085	85.363	NM_001256576
ENC1	hsa-miR-6813-5p	85.363	NM_001256576
ENC1	hsa-miR-8054	84.9313	NM_001256576
ENC1	hsa-miR-4753-3p	84.2984	NM_001256574
ENC1	hsa-miR-1185-1-3p	83.4649	NM_001256574
ENC1	hsa-let-7f-2-3p	83.4649	NM_001256574
ENC1	hsa-miR-1185-2-3p	83.4649	NM_001256574
ENC1	hsa-miR-4790-3p	82.8242	NM_001256574
ENC1	hsa-miR-451b	82.2543	NM_001256576
ENC1	hsa-miR-549a-3p	81.9631	NM_001256574
ENC1	hsa-miR-4709-3p	81.7882	NM_001256574

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating ENC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ENC1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ENC1	transfac_pro__M07397	ZNF148 (directAnnotation).
ENC1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ENC1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ENC1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ENC1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ENC1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ENC1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ENC1	transfac_pro__M01175	ZBTB7B (directAnnotation).
ENC1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ENC1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ENC1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ENC1	transfac_pro__M01303	SP1 (directAnnotation).
ENC1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ENC1	transfac_pro__M02090	E2F4 (directAnnotation).
ENC1	transfac_pro__M01714	KLF15 (directAnnotation).
ENC1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ENC1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ENC1	transfac_pro__M02089	E2F3 (directAnnotation).
ENC1	metacluster_3.14	WT1; WT1 (directAnnotation).
ENC1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ENC1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ENC1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ENC1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ENC1	cisbp__M07938	E2F1 (directAnnotation).
ENC1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ENC1	transfac_pro__M07436	WT1 (directAnnotation).
ENC1	transfac_pro__M02281	SP1 (directAnnotation).
ENC1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ENC1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ENC1	transfac_pro__M02898	SMAD3 (directAnnotation).
ENC1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ENC1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ENC1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ENC1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ENC1	cisbp__M08198	ELF1 (directAnnotation).
ENC1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ENC1	hdpi__HIP2	UBE2K (directAnnotation).
ENC1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ENC1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ENC1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ENC1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ENC1	hdpi__TIMELESS	TIMELESS (directAnnotation).
ENC1	transfac_pro__M04893	TAF1 (directAnnotation).
ENC1	cisbp__M00249	WT1 (directAnnotation).
ENC1	transfac_pro__M00430	E2F1 (directAnnotation).
ENC1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ENC1	hdpi__ZNF304	ZNF304 (directAnnotation).
ENC1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ENC1	transfac_pro__M00938	E2F1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."