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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ENAM

Summary for ENAM

Gene information	Gene symbol	ENAM
	Ensembl ID	ENSG00000132464
	Entrez ID	10117
	Gene name	enamelin
	Synonyms	AIH2
	Gene type	protein_coding
	UniProtAcc	Q9NRM1

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Dataset with differentially expressed gene: ENAM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.42791	1.26e-44

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Expression of ENAM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ENAM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ENAM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ENAM	hsa-miR-1185-2-3p	96.5849	NM_031889
ENAM	hsa-miR-1185-1-3p	96.5849	NM_031889
ENAM	hsa-let-7f-2-3p	96.5849	NM_031889
ENAM	hsa-miR-488-3p	92.8183	NM_031889
ENAM	hsa-miR-6130	90.8328	NM_031889
ENAM	hsa-miR-6133	90.8328	NM_031889
ENAM	hsa-miR-6127	90.8328	NM_031889
ENAM	hsa-miR-6129	90.8328	NM_031889
ENAM	hsa-miR-4510	90.8328	NM_031889
ENAM	hsa-miR-4709-3p	88.402	NM_031889
ENAM	hsa-miR-3190-3p	86.579	NM_031889
ENAM	hsa-miR-628-3p	84.9882	NM_031889
ENAM	hsa-miR-2110	84.87	NM_031889
ENAM	hsa-miR-4668-5p	83.7585	NM_031889
ENAM	hsa-miR-488-5p	83.4294	NM_031889
ENAM	hsa-miR-6077	82.4597	NM_031889
ENAM	hsa-miR-5680	80.6657	NM_031889

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Motifs and transcription factors (TFs) regulating ENAM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ENAM	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ENAM	metacluster_141.4	GLIS2 (directAnnotation).
ENAM	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
ENAM	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ENAM	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
ENAM	hdpi__FLI1	FLI1 (directAnnotation).
ENAM	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ENAM	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
ENAM	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
ENAM	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."