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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: EMP1

Summary for EMP1

Gene informationGene symbol

EMP1

Ensembl ID

ENSG00000134531

Entrez ID

2012

Gene nameepithelial membrane protein 1
SynonymsCL-20|TMP
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: EMP1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.8999420.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro-0.4870039.16e-35

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.893592.07e-04

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.934512.15e-13

GSE149214

PC9 cell lineCell lineLung cancerEGFR-mutated non-small cell lung cancer (NSCLC)Targeted therapyerlotinibNAMalignant cells-0.5911570.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.5587530.00e+00

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.4598456.33e-37

GSE131984_JQ1Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + paclitaxelNAMalignant cells0.2528472.92e-07

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.7215380.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.6282540.00e+00

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Expression of EMP1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to EMP1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EMP1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
EMP1hsa-miR-1212297.5251NM_001423
EMP1hsa-miR-101-3p94.0229NM_001423
EMP1hsa-miR-144-3p91.1501NM_001423
EMP1hsa-miR-654-3p89.3466NM_001423
EMP1hsa-miR-469889.1012NM_001423
EMP1hsa-miR-312388.0089NM_001423
EMP1hsa-miR-4667-3p86.4169NM_001423
EMP1hsa-miR-19b-2-5p86.2858NM_001423
EMP1hsa-miR-19a-5p86.2858NM_001423
EMP1hsa-miR-19b-1-5p86.2858NM_001423
EMP1hsa-miR-548n86.031NM_001423
EMP1hsa-miR-513b-3p85.7045NM_001423
EMP1hsa-miR-361-3p83.8765NM_001423
EMP1hsa-miR-6885-3p83.6274NM_001423
EMP1hsa-miR-147083.5521NM_001423
EMP1hsa-miR-4699-3p82.7515NM_001423
EMP1hsa-miR-7110-3p82.3458NM_001423
EMP1hsa-miR-708-3p82.153NM_001423
EMP1hsa-miR-508-5p82.0006NM_001423
EMP1hsa-miR-3200-5p80.8393NM_001423
EMP1hsa-miR-6826-3p80.1593NM_001423
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Motifs and transcription factors (TFs) regulating EMP1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
EMP1metacluster_56.4HSF1; HSF2; HSF2; HSF4 (directAnnotation).
EMP1transfac_pro__M05474ZNF639 (directAnnotation).
EMP1transfac_pro__M06944PRDM15 (directAnnotation).
EMP1cisbp__M00196BBX (inferredBy_Orthology).
EMP1taipale_tf_pairs__TEAD4_GATA3_NGATAASNNNRGWATGY_CAP_reprGATA3; TEAD4 (directAnnotation).
EMP1transfac_pro__M06192ZNF135 (directAnnotation).
EMP1tfdimers__MD00465CRX; IKZF1 (directAnnotation).
EMP1transfac_pro__M04856BATF (directAnnotation).
EMP1metacluster_56.3HSF2 (directAnnotation).
EMP1metacluster_137.2ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
EMP1taipale_tf_pairs__FLI1_DLX2_ACCGGAARTNNNYAATTA_HTDLX2; FLI1 (directAnnotation).
EMP1tfdimers__MD00276IRF1; STAT6 (directAnnotation).
EMP1tfdimers__MD00069IKZF1; PDX1 (directAnnotation).
EMP1jaspar__MA0185.1DEAF1 (inferredBy_Orthology).
EMP1taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
EMP1jaspar__MA0748.2YY2 (directAnnotation).
EMP1swissregulon__mm__Atf2ATF2 (inferredBy_Orthology).
EMP1transfac_pro__M05770ZNF77 (directAnnotation).
EMP1tfdimers__MD00490CDX2; SOX2 (directAnnotation).
EMP1transfac_pro__M06117ZNF23 (directAnnotation).
EMP1swissregulon__hs__EZH2EZH2 (directAnnotation).
EMP1transfac_pro__M02896SPI1 (inferredBy_Orthology).
EMP1taipale_tf_pairs__GCM2_PITX1_RTRCGGGSGATTAN_CAP_reprGCM2; PITX1 (directAnnotation).
EMP1taipale_cyt_meth__LMX1B_CTCGTTAW_FL_methLMX1B (directAnnotation).
EMP1transfac_pro__M06907ZFP3 (inferredBy_Orthology).
EMP1metacluster_51.15HOXA5 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."