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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELP1

Summary for ELP1

Gene information	Gene symbol	ELP1
	Ensembl ID	ENSG00000070061
	Entrez ID	8518
	Gene name	elongator acetyltransferase complex subunit 1
	Synonyms	DYS\|IKAP\|IKBKAP\|IKI3\|TOT1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ELP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.480735	5.11e-39

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Expression of ELP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELP1	hsa-miR-12131	93.9901	NM_001318360
ELP1	hsa-miR-4500	90.0421	NM_001318360
ELP1	hsa-miR-152-5p	89.7735	NM_003640
ELP1	hsa-miR-4682	89.7113	NM_003640
ELP1	hsa-miR-3200-5p	88.4711	NM_003640
ELP1	hsa-miR-6794-3p	88.2991	NM_003640
ELP1	hsa-let-7b-5p	88.2584	NM_001318360
ELP1	hsa-let-7e-5p	88.2584	NM_001318360
ELP1	hsa-let-7f-5p	88.2584	NM_001318360
ELP1	hsa-miR-4458	88.2584	NM_001318360
ELP1	hsa-let-7a-5p	88.2584	NM_001318360
ELP1	hsa-let-7g-5p	88.2584	NM_001318360
ELP1	hsa-miR-98-5p	88.2584	NM_001318360
ELP1	hsa-let-7i-5p	88.2584	NM_001318360
ELP1	hsa-let-7c-5p	88.2584	NM_001318360
ELP1	hsa-let-7d-5p	88.2584	NM_001318360
ELP1	hsa-miR-494-3p	88.149	NM_003640
ELP1	hsa-miR-3661	86.1154	NM_003640
ELP1	hsa-miR-431-5p	86.0808	NM_003640
ELP1	hsa-miR-7156-3p	84.8438	NM_003640
ELP1	hsa-miR-3927-3p	83.5259	NM_001318360
ELP1	hsa-miR-6831-5p	83.5259	NM_001318360
ELP1	hsa-miR-3121-3p	83.3768	NM_003640
ELP1	hsa-miR-631	82.8451	NM_003640
ELP1	hsa-miR-1251-5p	82.6926	NM_003640

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Motifs and transcription factors (TFs) regulating ELP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."