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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELOVL3

Summary for ELOVL3

Gene information	Gene symbol	ELOVL3
	Ensembl ID	ENSG00000119915
	Entrez ID	83401
	Gene name	ELOVL fatty acid elongase 3
	Synonyms	CIG-30
	Gene type	protein_coding
	UniProtAcc	Q9HB03

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Dataset with differentially expressed gene: ELOVL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.39229	0.00e+00

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Expression of ELOVL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELOVL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELOVL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELOVL3	hsa-miR-4713-5p	94.4831	NM_152310
ELOVL3	hsa-miR-5706	91.2443	NM_152310
ELOVL3	hsa-miR-4782-5p	91.2443	NM_152310
ELOVL3	hsa-miR-629-3p	91.0145	NM_152310
ELOVL3	hsa-miR-23b-3p	90.0057	NM_152310
ELOVL3	hsa-miR-23c	90.0057	NM_152310
ELOVL3	hsa-miR-23a-3p	90.0057	NM_152310
ELOVL3	hsa-miR-6867-3p	88.8977	NM_152310
ELOVL3	hsa-miR-3185	88.1522	NM_152310
ELOVL3	hsa-miR-653-5p	87.2454	NM_152310
ELOVL3	hsa-miR-150-5p	87.1463	NM_152310
ELOVL3	hsa-miR-2116-3p	86.0221	NM_152310
ELOVL3	hsa-miR-6501-3p	83.8368	NM_152310
ELOVL3	hsa-miR-532-3p	83.2316	NM_152310
ELOVL3	hsa-miR-4516	82.4569	NM_152310
ELOVL3	hsa-miR-494-3p	82.2008	NM_152310

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Motifs and transcription factors (TFs) regulating ELOVL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELOVL3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ELOVL3	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."