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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELOA

Summary for ELOA

Gene information	Gene symbol	ELOA
	Ensembl ID	ENSG00000011007
	Entrez ID	6924
	Gene name	elongin A
	Synonyms	SIII\|TCEB3\|TCEB3A
	Gene type	protein_coding
	UniProtAcc	Q14241

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Dataset with differentially expressed gene: ELOA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.928696	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.287229	0.00e+00

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Expression of ELOA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELOA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELOA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELOA	hsa-miR-637	96.5125	NM_003198
ELOA	hsa-miR-452-3p	92.3141	NM_003198
ELOA	hsa-miR-548n	91.581	NM_003198
ELOA	hsa-miR-455-5p	91.1749	NM_003198
ELOA	hsa-miR-2114-3p	88.0107	NM_003198
ELOA	hsa-miR-6823-3p	87.6599	NM_003198
ELOA	hsa-miR-4475	86.885	NM_003198
ELOA	hsa-miR-6759-3p	85.5131	NM_003198
ELOA	hsa-miR-5010-5p	85.469	NM_003198
ELOA	hsa-miR-4525	85.469	NM_003198
ELOA	hsa-miR-520d-5p	84.4135	NM_003198
ELOA	hsa-miR-524-5p	84.4135	NM_003198
ELOA	hsa-miR-149-5p	83.8634	NM_003198
ELOA	hsa-miR-4786-5p	83.7508	NM_003198
ELOA	hsa-miR-29b-2-5p	82.2318	NM_003198
ELOA	hsa-miR-140-3p	82.0112	NM_003198
ELOA	hsa-miR-92b-3p	81.3535	NM_003198
ELOA	hsa-miR-32-5p	81.3535	NM_003198
ELOA	hsa-miR-367-3p	81.3535	NM_003198
ELOA	hsa-miR-25-3p	81.3535	NM_003198
ELOA	hsa-miR-92a-3p	81.3535	NM_003198
ELOA	hsa-miR-363-3p	81.3535	NM_003198
ELOA	hsa-miR-6752-3p	80.0094	NM_003198

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Motifs and transcription factors (TFs) regulating ELOA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."