Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELMO1

Summary for ELMO1

Gene information	Gene symbol	ELMO1
	Ensembl ID	ENSG00000155849
	Entrez ID	9844
	Gene name	engulfment and cell motility 1
	Synonyms	CED-12\|CED12\|ELMO-1\|KIAA0281
	Gene type	protein_coding
	UniProtAcc	Q92556

Top

Dataset with differentially expressed gene: ELMO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.350076	2.76e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.373116	0.00e+00

Top

Expression of ELMO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ELMO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ELMO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELMO1	hsa-miR-6740-5p	99.3929	NM_130442
ELMO1	hsa-miR-4517	94.9449	NM_130442
ELMO1	hsa-miR-5195-3p	94.5884	NM_001039459
ELMO1	hsa-miR-4328	93.8992	NM_001039459
ELMO1	hsa-miR-145-5p	92.9781	NM_001039459
ELMO1	hsa-miR-7106-5p	92.8355	NM_130442
ELMO1	hsa-miR-185-3p	92.4105	NM_001039459
ELMO1	hsa-miR-5692a	89.9584	NM_001039459
ELMO1	hsa-miR-218-5p	89.5117	NM_001039459
ELMO1	hsa-miR-6745	89.4312	NM_130442
ELMO1	hsa-miR-182-5p	88.7286	NM_130442
ELMO1	hsa-miR-335-3p	87.9333	NM_130442
ELMO1	hsa-miR-363-5p	87.6795	NM_130442
ELMO1	hsa-miR-4306	86.9466	NM_130442
ELMO1	hsa-miR-4441	85.5631	NM_130442
ELMO1	hsa-miR-6838-3p	84.2582	NM_130442
ELMO1	hsa-miR-450a-1-3p	83.4585	NM_130442
ELMO1	hsa-miR-6805-3p	83.217	NM_130442
ELMO1	hsa-miR-5691	83.217	NM_130442
ELMO1	hsa-miR-128-3p	82.4033	NM_001039459
ELMO1	hsa-miR-216a-3p	82.4033	NM_001039459
ELMO1	hsa-miR-6892-5p	81.9925	NM_130442
ELMO1	hsa-miR-6813-5p	81.6031	NM_001039459
ELMO1	hsa-miR-6085	81.6031	NM_001039459
ELMO1	hsa-miR-6770-5p	80.6413	NM_001039459
ELMO1	hsa-miR-3714	80.4499	NM_001039459

Page: 1

Top

Motifs and transcription factors (TFs) regulating ELMO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELMO1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ELMO1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ELMO1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
ELMO1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ELMO1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
ELMO1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ELMO1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ELMO1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ELMO1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ELMO1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
ELMO1	transfac_pro__M04748	GABPA (directAnnotation).
ELMO1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ELMO1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
ELMO1	transfac_pro__M06032	ZNF727 (directAnnotation).
ELMO1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
ELMO1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ELMO1	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
ELMO1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
ELMO1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
ELMO1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ELMO1	transfac_pro__M05993	ZNF711 (directAnnotation).
ELMO1	hdpi__FEZF2	FEZF2 (directAnnotation).
ELMO1	metacluster_198.3	ZFP64 (directAnnotation).
ELMO1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ELMO1	hdpi__NRL	NRL (directAnnotation).
ELMO1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ELMO1	tfdimers__MD00483	ZBTB14 (directAnnotation).
ELMO1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ELMO1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
ELMO1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."