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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ELK3

Summary for ELK3

Gene information	Gene symbol	ELK3
	Ensembl ID	ENSG00000111145
	Entrez ID	2004
	Gene name	ETS transcription factor ELK3
	Synonyms	ERP\|NET\|SAP2
	Gene type	protein_coding
	UniProtAcc	P41970

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Dataset with differentially expressed gene: ELK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.965299	1.17e-05
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.319098	6.55e-27
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.293972	4.38e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.341108	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.674223	0.00e+00

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Expression of ELK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELK3	hsa-miR-584-3p	99.3498	NM_005230
ELK3	hsa-miR-4716-5p	96.0505	NM_005230
ELK3	hsa-miR-4645-3p	94.1936	NM_005230
ELK3	hsa-miR-9983-3p	93.375	NM_005230
ELK3	hsa-miR-129-5p	92.7931	NM_005230
ELK3	hsa-miR-545-5p	92.2149	NM_005230
ELK3	hsa-miR-5701	91.7798	NM_005230
ELK3	hsa-miR-200a-3p	91.4657	NM_005230
ELK3	hsa-miR-141-3p	91.4657	NM_005230
ELK3	hsa-miR-8084	91.1079	NM_005230
ELK3	hsa-miR-4277	91.0236	NM_005230
ELK3	hsa-miR-135a-5p	90.1416	NM_005230
ELK3	hsa-miR-507	89.8098	NM_005230
ELK3	hsa-miR-135b-5p	89.6441	NM_005230
ELK3	hsa-miR-6792-5p	89.2044	NM_005230
ELK3	hsa-miR-4328	88.7212	NM_005230
ELK3	hsa-miR-557	88.578	NM_005230
ELK3	hsa-miR-8485	88.0687	NM_005230
ELK3	hsa-miR-6516-5p	87.6325	NM_005230
ELK3	hsa-miR-548ah-5p	87.0136	NM_005230
ELK3	hsa-miR-335-3p	85.7719	NM_005230
ELK3	hsa-miR-3613-3p	84.8739	NM_005230
ELK3	hsa-miR-7849-3p	84.8223	NM_005230
ELK3	hsa-miR-3680-3p	84.401	NM_005230
ELK3	hsa-miR-20a-5p	83.9639	NM_005230
ELK3	hsa-miR-106b-5p	83.9639	NM_005230
ELK3	hsa-miR-5582-5p	83.7826	NM_005230
ELK3	hsa-miR-4299	82.8939	NM_005230
ELK3	hsa-miR-20b-5p	82.657	NM_005230
ELK3	hsa-miR-17-5p	82.657	NM_005230
ELK3	hsa-miR-526b-3p	82.657	NM_005230
ELK3	hsa-miR-93-5p	82.657	NM_005230
ELK3	hsa-miR-519d-3p	82.657	NM_005230
ELK3	hsa-miR-106a-5p	82.657	NM_005230
ELK3	hsa-miR-3609	82.3146	NM_005230
ELK3	hsa-miR-6124	81.4555	NM_005230
ELK3	hsa-miR-330-3p	80.3801	NM_005230

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Motifs and transcription factors (TFs) regulating ELK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELK3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ELK3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ELK3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ELK3	transfac_pro__M04950	EGR1 (directAnnotation).
ELK3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ELK3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ELK3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ELK3	transfac_pro__M00652	NRF1 (directAnnotation).
ELK3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ELK3	transfac_pro__M04866	HDAC2 (directAnnotation).
ELK3	jaspar__MA1122.1	TFDP1 (directAnnotation).
ELK3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ELK3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ELK3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ELK3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ELK3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ELK3	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ELK3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ELK3	transfac_pro__M04617	ZBTB7A (directAnnotation).
ELK3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ELK3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ELK3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ELK3	transfac_pro__M07387	ZBTB7A (directAnnotation).
ELK3	transfac_pro__M07436	WT1 (directAnnotation).
ELK3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ELK3	transfac_pro__M00716	ZBTB14 (directAnnotation).
ELK3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ELK3	hdpi__HIP2	UBE2K (directAnnotation).
ELK3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ELK3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ELK3	transfac_pro__M04893	TAF1 (directAnnotation).
ELK3	transfac_pro__M03876	ZBTB33 (directAnnotation).
ELK3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ELK3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ELK3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ELK3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ELK3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ELK3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
ELK3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ELK3	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ELK3	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ELK3	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
ELK3	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
ELK3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ELK3	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
ELK3	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
ELK3	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ELK3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ELK3	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
ELK3	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ELK3	metacluster_191.3	down	Malignant cells	GSE139386	NA
ELK3	metacluster_166.4	down	Malignant cells	GSE139386	NA
ELK3	metacluster_138.2	down	Malignant cells	GSE139386	NA
ELK3	metacluster_191.3	up	Malignant cells	GSE153697	NA
ELK3	metacluster_166.4	up	Malignant cells	GSE153697	NA
ELK3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	up	Malignant cells	GSE153697	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."