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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ELF3

Summary for ELF3

Gene information	Gene symbol	ELF3
	Ensembl ID	ENSG00000163435
	Entrez ID	1999
	Gene name	E74 like ETS transcription factor 3
	Synonyms	EPR-1\|ERT\|ESE-1\|ESX
	Gene type	protein_coding
	UniProtAcc	P78545

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Dataset with differentially expressed gene: ELF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.662977	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.504177	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.500406	2.79e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.617758	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.37261	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.628093	1.74e-30

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Expression of ELF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELF3	hsa-miR-4288	95.1407	NM_004433
ELF3	hsa-miR-6719-3p	93.8701	NM_004433
ELF3	hsa-miR-632	91.72	NM_004433
ELF3	hsa-miR-7114-5p	90.8564	NM_001114309
ELF3	hsa-miR-455-3p	84.2363	NM_001114309
ELF3	hsa-miR-3183	83.44	NM_001114309
ELF3	hsa-miR-4723-3p	83.44	NM_001114309
ELF3	hsa-miR-6769b-3p	83.44	NM_001114309
ELF3	hsa-miR-585-5p	82.2559	NM_004433
ELF3	hsa-miR-10399-5p	81.746	NM_004433
ELF3	hsa-miR-6504-3p	81.746	NM_004433
ELF3	hsa-miR-1301-3p	80.9757	NM_004433
ELF3	hsa-miR-5047	80.9757	NM_004433
ELF3	hsa-miR-5088-3p	80.764	NM_004433

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Motifs and transcription factors (TFs) regulating ELF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELF3	hdpi__TFAM	TFAM (directAnnotation).
ELF3	taipale_tf_pairs__MGA_DLX2_SYAATTANWGGTGYGA_CAP	DLX2; MGA (directAnnotation).
ELF3	transfac_pro__M05981	ZNF233 (directAnnotation).
ELF3	transfac_pro__M06609	ZKSCAN4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ELF3	metacluster_166.4	up	Malignant cells	GSE139386	NA
ELF3	metacluster_166.4	up	Malignant cells	GSE163836	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."