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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELAVL4

Summary for ELAVL4

Gene information	Gene symbol	ELAVL4
	Ensembl ID	ENSG00000162374
	Entrez ID	1996
	Gene name	ELAV like RNA binding protein 4
	Synonyms	HUD\|PNEM
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ELAVL4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.262388	0.00e+00

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Expression of ELAVL4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELAVL4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELAVL4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELAVL4	hsa-miR-5011-5p	99.9939	NM_001144774
ELAVL4	hsa-miR-190a-3p	99.9663	NM_001144774
ELAVL4	hsa-miR-4795-3p	99.5777	NM_001324217
ELAVL4	hsa-miR-9983-3p	99.4722	NM_001144774
ELAVL4	hsa-miR-129-5p	99.1695	NM_001144774
ELAVL4	hsa-miR-6867-5p	99.1083	NM_001144774
ELAVL4	hsa-miR-450b-5p	99.0653	NM_001144774
ELAVL4	hsa-miR-5003-5p	98.9528	NM_001144774
ELAVL4	hsa-miR-3679-3p	97.9987	NM_001144774
ELAVL4	hsa-miR-3148	97.6766	NM_001144774
ELAVL4	hsa-miR-8485	97.6555	NM_001144774
ELAVL4	hsa-miR-569	97.5369	NM_001144774
ELAVL4	hsa-miR-126-5p	97.2706	NM_001324217
ELAVL4	hsa-miR-3059-5p	97.0269	NM_001144774
ELAVL4	hsa-miR-5692a	96.9332	NM_001144774
ELAVL4	hsa-miR-3163	96.644	NM_001144774
ELAVL4	hsa-miR-375-3p	96.5858	NM_001144774
ELAVL4	hsa-miR-607	96.1686	NM_001324217
ELAVL4	hsa-miR-196a-3p	95.9279	NM_001144774
ELAVL4	hsa-miR-4778-3p	95.6508	NM_001144774
ELAVL4	hsa-miR-340-5p	95.1252	NM_001144774
ELAVL4	hsa-miR-6873-3p	94.7694	NM_001144774
ELAVL4	hsa-miR-556-3p	94.7372	NM_001144774
ELAVL4	hsa-miR-6739-3p	94.5199	NM_001144774
ELAVL4	hsa-miR-5006-3p	94.4787	NM_001144774
ELAVL4	hsa-miR-4755-5p	94.4787	NM_001144774
ELAVL4	hsa-miR-7112-3p	94.3346	NM_001144774
ELAVL4	hsa-miR-4446-5p	94.3169	NM_001144774
ELAVL4	hsa-miR-3941	94.1223	NM_001144774
ELAVL4	hsa-miR-7844-5p	94.0492	NM_001144774
ELAVL4	hsa-miR-410-3p	93.9519	NM_001144774
ELAVL4	hsa-miR-3680-5p	93.8904	NM_001324217
ELAVL4	hsa-miR-5700	93.7538	NM_001144774
ELAVL4	hsa-miR-6507-3p	93.478	NM_001144774
ELAVL4	hsa-miR-182-5p	93.2724	NM_001144774
ELAVL4	hsa-miR-603	93.0334	NM_001144774
ELAVL4	hsa-miR-1231	92.9565	NM_001144774
ELAVL4	hsa-miR-7110-3p	92.8353	NM_001144774
ELAVL4	hsa-miR-548c-3p	92.6733	NM_001144774
ELAVL4	hsa-miR-4711-5p	92.4481	NM_001144774
ELAVL4	hsa-miR-4302	92.4312	NM_001144774
ELAVL4	hsa-miR-670-5p	92.3521	NM_001144774
ELAVL4	hsa-miR-548k	92.0036	NM_001144774
ELAVL4	hsa-miR-548av-5p	92.0036	NM_001144774
ELAVL4	hsa-miR-8054	92.0036	NM_001144774
ELAVL4	hsa-miR-651-3p	91.677	NM_001144774
ELAVL4	hsa-miR-499a-5p	91.6084	NM_001144774
ELAVL4	hsa-miR-4282	91.5704	NM_001144774
ELAVL4	hsa-miR-23a-3p	91.5584	NM_001144774
ELAVL4	hsa-miR-23b-3p	91.5584	NM_001144774

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Motifs and transcription factors (TFs) regulating ELAVL4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELAVL4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ELAVL4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ELAVL4	transfac_pro__M07397	ZNF148 (directAnnotation).
ELAVL4	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ELAVL4	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ELAVL4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ELAVL4	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ELAVL4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ELAVL4	metacluster_7.13	ZFX (directAnnotation).
ELAVL4	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ELAVL4	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ELAVL4	transfac_pro__M01175	ZBTB7B (directAnnotation).
ELAVL4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ELAVL4	tfdimers__MD00151	CHURC1 (directAnnotation).
ELAVL4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ELAVL4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ELAVL4	transfac_pro__M01303	SP1 (directAnnotation).
ELAVL4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ELAVL4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ELAVL4	transfac_pro__M02090	E2F4 (directAnnotation).
ELAVL4	transfac_pro__M01714	KLF15 (directAnnotation).
ELAVL4	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ELAVL4	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ELAVL4	transfac_pro__M02089	E2F3 (directAnnotation).
ELAVL4	metacluster_3.14	WT1; WT1 (directAnnotation).
ELAVL4	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ELAVL4	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ELAVL4	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ELAVL4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ELAVL4	cisbp__M07938	E2F1 (directAnnotation).
ELAVL4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ELAVL4	transfac_pro__M07436	WT1 (directAnnotation).
ELAVL4	transfac_pro__M02281	SP1 (directAnnotation).
ELAVL4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ELAVL4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ELAVL4	transfac_pro__M02898	SMAD3 (directAnnotation).
ELAVL4	transfac_public__M00491	PATZ1 (directAnnotation).
ELAVL4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ELAVL4	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."