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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EIF4H

Summary for EIF4H

Gene information	Gene symbol	EIF4H
	Ensembl ID	ENSG00000106682
	Entrez ID	7458
	Gene name	eukaryotic translation initiation factor 4H
	Synonyms	KIAA0038\|WBSCR1\|WSCR1
	Gene type	protein_coding
	UniProtAcc	Q15056

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Dataset with differentially expressed gene: EIF4H

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.515282	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.490476	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.291672	4.64e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.350425	1.48e-31
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.65619	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.33316	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.37661	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.348673	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.339686	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.251771	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.270097	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.320878	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.465902	0.00e+00

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Expression of EIF4H in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF4H

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF4H

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF4H	hsa-miR-651-3p	98.012	NM_022170
EIF4H	hsa-miR-6715b-5p	95.3182	NM_022170
EIF4H	hsa-miR-4269	95.3182	NM_022170
EIF4H	hsa-miR-4722-5p	93.9208	NM_022170
EIF4H	hsa-miR-215-3p	93.5031	NM_022170
EIF4H	hsa-miR-497-3p	90.9626	NM_022170
EIF4H	hsa-miR-6830-3p	88.8643	NM_022170
EIF4H	hsa-miR-218-2-3p	88.489	NM_022170
EIF4H	hsa-miR-4743-3p	88.2967	NM_022170
EIF4H	hsa-miR-511-5p	87.0612	NM_022170
EIF4H	hsa-miR-4666b	84.9572	NM_022170
EIF4H	hsa-miR-6739-3p	83.6359	NM_022170
EIF4H	hsa-miR-4533	81.3471	NM_022170
EIF4H	hsa-miR-597-3p	80.6462	NM_022170
EIF4H	hsa-miR-182-3p	80.6462	NM_022170
EIF4H	hsa-miR-5700	80.133	NM_022170

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Motifs and transcription factors (TFs) regulating EIF4H

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF4H	metacluster_7.13	ZFX (directAnnotation).
EIF4H	cisbp__M01863	ZNF711 (inferredBy_Orthology).
EIF4H	metacluster_151.2	ZNF23 (directAnnotation).
EIF4H	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
EIF4H	transfac_pro__M05479	ZNF580 (directAnnotation).
EIF4H	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
EIF4H	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
EIF4H	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
EIF4H	metacluster_182.10	ZFX (directAnnotation).
EIF4H	jaspar__MA0748.2	YY2 (directAnnotation).
EIF4H	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
EIF4H	jaspar__MA0079.5	SP1 (directAnnotation).
EIF4H	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
EIF4H	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EIF4H	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
EIF4H	transfac_pro__M04950	EGR1 (directAnnotation).
EIF4H	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EIF4H	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
EIF4H	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
EIF4H	transfac_pro__M00652	NRF1 (directAnnotation).
EIF4H	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EIF4H	transfac_pro__M04866	HDAC2 (directAnnotation).
EIF4H	jaspar__MA1122.1	TFDP1 (directAnnotation).
EIF4H	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EIF4H	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
EIF4H	transfac_pro__M01783	SP2 (directAnnotation).
EIF4H	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
EIF4H	cisbp__M00341	PAX6 (directAnnotation).
EIF4H	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
EIF4H	transfac_pro__M01253	CNOT3 (directAnnotation).
EIF4H	cisbp__M00968	MTF2 (directAnnotation).
EIF4H	transfac_pro__M04817	ZBTB33 (directAnnotation).
EIF4H	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
EIF4H	transfac_pro__M02089	E2F3 (directAnnotation).
EIF4H	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
EIF4H	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
EIF4H	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
EIF4H	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
EIF4H	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
EIF4H	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
EIF4H	metacluster_161.2	LHX8 (directAnnotation).
EIF4H	metacluster_161.4	LHX9 (directAnnotation).
EIF4H	metacluster_141.2	E2F2; E2F3 (directAnnotation).
EIF4H	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EIF4H	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
EIF4H	transfac_pro__M07392	PITX3 (directAnnotation).
EIF4H	metacluster_141.4	GLIS2 (directAnnotation).
EIF4H	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
EIF4H	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
EIF4H	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."