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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EIF4G3

Summary for EIF4G3

Gene information	Gene symbol	EIF4G3
	Ensembl ID	ENSG00000075151
	Entrez ID	8672
	Gene name	eukaryotic translation initiation factor 4 gamma 3
	Synonyms	eIF4GII
	Gene type	protein_coding
	UniProtAcc	O43432

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Dataset with differentially expressed gene: EIF4G3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.310007	7.78e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.254492	3.90e-31

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Expression of EIF4G3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF4G3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF4G3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF4G3	hsa-miR-4482-3p	98.5242	NM_001198801
EIF4G3	hsa-miR-7159-3p	97.0337	NM_001198801
EIF4G3	hsa-miR-6739-3p	95.905	NM_003760
EIF4G3	hsa-miR-4443	95.2817	NM_001198803
EIF4G3	hsa-miR-7108-3p	94.374	NM_003760
EIF4G3	hsa-miR-5010-3p	93.8583	NM_003760
EIF4G3	hsa-miR-495-3p	92.7732	NM_001198801
EIF4G3	hsa-miR-6516-5p	92.1223	NM_001198801
EIF4G3	hsa-miR-520g-3p	90.6531	NM_003760
EIF4G3	hsa-miR-520h	90.6531	NM_003760
EIF4G3	hsa-miR-5688	90.3743	NM_001198801
EIF4G3	hsa-miR-5692a	89.221	NM_001198801
EIF4G3	hsa-miR-381-3p	88.8425	NM_003760
EIF4G3	hsa-miR-300	88.8425	NM_003760
EIF4G3	hsa-miR-1237-3p	88.504	NM_003760
EIF4G3	hsa-miR-2052	87.8685	NM_003760
EIF4G3	hsa-miR-511-5p	87.3899	NM_003760
EIF4G3	hsa-miR-4666a-5p	86.8347	NM_003760
EIF4G3	hsa-let-7a-3p	86.0339	NM_003760
EIF4G3	hsa-let-7b-3p	86.0339	NM_003760
EIF4G3	hsa-let-7f-1-3p	86.0339	NM_003760
EIF4G3	hsa-miR-98-3p	86.0339	NM_003760
EIF4G3	hsa-miR-4677-5p	85.8694	NM_003760
EIF4G3	hsa-miR-4738-3p	85.4562	NM_003760
EIF4G3	hsa-miR-369-3p	84.5191	NM_001198801
EIF4G3	hsa-miR-8070	83.9717	NM_003760
EIF4G3	hsa-miR-9983-3p	83.9712	NM_003760
EIF4G3	hsa-miR-548av-3p	83.5199	NM_003760
EIF4G3	hsa-miR-3612	83.4567	NM_001198803
EIF4G3	hsa-miR-650	83.4567	NM_001198803
EIF4G3	hsa-miR-6757-3p	83.1423	NM_003760
EIF4G3	hsa-miR-362-3p	82.0292	NM_001198803
EIF4G3	hsa-miR-329-3p	82.0292	NM_001198803
EIF4G3	hsa-miR-297	81.7412	NM_001198801
EIF4G3	hsa-miR-5003-3p	80.9227	NM_003760
EIF4G3	hsa-miR-6802-3p	80.5146	NM_003760

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Motifs and transcription factors (TFs) regulating EIF4G3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF4G3	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
EIF4G3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
EIF4G3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
EIF4G3	hdpi__ETV4	ETV4 (directAnnotation).
EIF4G3	transfac_pro__M05628	ZNF735 (directAnnotation).
EIF4G3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
EIF4G3	jaspar__MA0079.5	SP1 (directAnnotation).
EIF4G3	transfac_pro__M04826	EP300 (directAnnotation).
EIF4G3	transfac_pro__M04794	TAF1 (directAnnotation).
EIF4G3	jaspar__MA0748.2	YY2 (directAnnotation).
EIF4G3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."