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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EIF4EBP2

Summary for EIF4EBP2

Gene information	Gene symbol	EIF4EBP2
	Ensembl ID	ENSG00000148730
	Entrez ID	1979
	Gene name	eukaryotic translation initiation factor 4E binding protein 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13542

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Dataset with differentially expressed gene: EIF4EBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.460735	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.317802	1.88e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.455253	2.57e-36
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.275119	7.37e-07

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Expression of EIF4EBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF4EBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF4EBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF4EBP2	hsa-miR-4441	97.5775	NM_004096
EIF4EBP2	hsa-miR-7106-5p	96.0629	NM_004096
EIF4EBP2	hsa-miR-651-3p	94.506	NM_004096
EIF4EBP2	hsa-miR-4270	93.8949	NM_004096
EIF4EBP2	hsa-miR-6754-5p	93.6942	NM_004096
EIF4EBP2	hsa-miR-3926	93.63	NM_004096
EIF4EBP2	hsa-miR-9851-3p	93.3143	NM_004096
EIF4EBP2	hsa-miR-6749-3p	92.9391	NM_004096
EIF4EBP2	hsa-miR-548s	92.8766	NM_004096
EIF4EBP2	hsa-miR-4306	92.5164	NM_004096
EIF4EBP2	hsa-miR-593-5p	91.3123	NM_004096
EIF4EBP2	hsa-miR-4728-5p	90.8953	NM_004096
EIF4EBP2	hsa-miR-6785-5p	90.8953	NM_004096
EIF4EBP2	hsa-miR-3913-5p	90.3131	NM_004096
EIF4EBP2	hsa-miR-5195-3p	89.58	NM_004096
EIF4EBP2	hsa-miR-302a-5p	89.5638	NM_004096
EIF4EBP2	hsa-miR-145-5p	89.3871	NM_004096
EIF4EBP2	hsa-miR-4451	88.6464	NM_004096
EIF4EBP2	hsa-miR-627-3p	88.2055	NM_004096
EIF4EBP2	hsa-miR-4659a-3p	88.1083	NM_004096
EIF4EBP2	hsa-miR-4659b-3p	88.1083	NM_004096
EIF4EBP2	hsa-miR-149-3p	87.6326	NM_004096
EIF4EBP2	hsa-miR-6883-5p	87.6326	NM_004096
EIF4EBP2	hsa-miR-3122	86.8217	NM_004096
EIF4EBP2	hsa-miR-7106-3p	86.5774	NM_004096
EIF4EBP2	hsa-miR-3692-5p	86.1163	NM_004096
EIF4EBP2	hsa-miR-548c-3p	85.8891	NM_004096
EIF4EBP2	hsa-miR-4487	85.8621	NM_004096
EIF4EBP2	hsa-miR-6077	85.7623	NM_004096
EIF4EBP2	hsa-miR-7-5p	85.7029	NM_004096
EIF4EBP2	hsa-miR-892b	85.3282	NM_004096
EIF4EBP2	hsa-miR-4744	84.6017	NM_004096
EIF4EBP2	hsa-miR-764	84.4282	NM_004096
EIF4EBP2	hsa-miR-96-5p	84.3485	NM_004096
EIF4EBP2	hsa-miR-6734-3p	83.873	NM_004096
EIF4EBP2	hsa-miR-29a-5p	83.0974	NM_004096
EIF4EBP2	hsa-miR-1252-5p	83.0428	NM_004096
EIF4EBP2	hsa-miR-6799-5p	82.3554	NM_004096
EIF4EBP2	hsa-miR-4330	82.2146	NM_004096
EIF4EBP2	hsa-miR-3059-5p	81.6195	NM_004096
EIF4EBP2	hsa-miR-1271-5p	81.5266	NM_004096
EIF4EBP2	hsa-miR-12133	81.5266	NM_004096
EIF4EBP2	hsa-miR-3120-3p	81.447	NM_004096
EIF4EBP2	hsa-miR-320e	80.7758	NM_004096
EIF4EBP2	hsa-miR-1200	80.438	NM_004096

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Motifs and transcription factors (TFs) regulating EIF4EBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF4EBP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EIF4EBP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
EIF4EBP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
EIF4EBP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EIF4EBP2	transfac_pro__M04866	HDAC2 (directAnnotation).
EIF4EBP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
EIF4EBP2	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
EIF4EBP2	jaspar__MA0079.5	SP1 (directAnnotation).
EIF4EBP2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
EIF4EBP2	transfac_pro__M01253	CNOT3 (directAnnotation).
EIF4EBP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
EIF4EBP2	transfac_pro__M05712	ZNF134 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."