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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EIF4E3

Summary for EIF4E3

Gene information	Gene symbol	EIF4E3
	Ensembl ID	ENSG00000163412
	Entrez ID	317649
	Gene name	eukaryotic translation initiation factor 4E family member 3
	Synonyms	MGC39820
	Gene type	protein_coding
	UniProtAcc	Q8N5X7

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Dataset with differentially expressed gene: EIF4E3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.84109	5.80e-06

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Expression of EIF4E3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF4E3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF4E3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF4E3	hsa-miR-3613-3p	98.6793	NM_001134650
EIF4E3	hsa-miR-656-3p	97.0759	NM_173359
EIF4E3	hsa-miR-570-3p	95.2326	NM_001134650
EIF4E3	hsa-miR-561-3p	94.9494	NM_173359
EIF4E3	hsa-miR-4478	93.1274	NM_173359
EIF4E3	hsa-miR-590-3p	93.0126	NM_173359
EIF4E3	hsa-miR-9-5p	92.9212	NM_001134650
EIF4E3	hsa-miR-3929	91.3155	NM_173359
EIF4E3	hsa-miR-759	91.2695	NM_173359
EIF4E3	hsa-miR-146a-3p	91.2648	NM_173359
EIF4E3	hsa-miR-4277	91.19	NM_173359
EIF4E3	hsa-miR-335-3p	91.1063	NM_173359
EIF4E3	hsa-miR-4775	90.395	NM_173359
EIF4E3	hsa-miR-548e-5p	90.1463	NM_001134650
EIF4E3	hsa-miR-4695-3p	89.9769	NM_001134650
EIF4E3	hsa-miR-6868-3p	88.8503	NM_173359
EIF4E3	hsa-miR-5584-5p	88.5475	NM_001134650
EIF4E3	hsa-miR-34c-3p	87.8317	NM_173359
EIF4E3	hsa-miR-5010-3p	86.9995	NM_173359
EIF4E3	hsa-miR-597-5p	86.8578	NM_001134650
EIF4E3	hsa-miR-545-3p	86.8062	NM_173359
EIF4E3	hsa-miR-4753-5p	86.6093	NM_173359
EIF4E3	hsa-miR-8070	86.1314	NM_173359
EIF4E3	hsa-miR-4445-3p	85.7908	NM_173359
EIF4E3	hsa-miR-548al	85.7908	NM_173359
EIF4E3	hsa-miR-5681a	85.4127	NM_173359
EIF4E3	hsa-miR-548c-3p	85.386	NM_001134650
EIF4E3	hsa-miR-5680	85.2662	NM_001134650
EIF4E3	hsa-miR-6777-3p	85.0872	NM_173359
EIF4E3	hsa-miR-12136	84.7301	NM_001134650
EIF4E3	hsa-miR-2115-3p	84.5936	NM_001134650
EIF4E3	hsa-miR-153-5p	84.4045	NM_173359
EIF4E3	hsa-miR-6811-3p	83.9948	NM_173359
EIF4E3	hsa-miR-5003-5p	83.8801	NM_173359
EIF4E3	hsa-miR-8080	83.499	NM_001134650
EIF4E3	hsa-miR-1272	83.464	NM_173359
EIF4E3	hsa-miR-6788-5p	82.8902	NM_173359
EIF4E3	hsa-miR-30c-1-3p	82.8902	NM_173359
EIF4E3	hsa-miR-30c-2-3p	82.8902	NM_173359
EIF4E3	hsa-miR-4303	82.7076	NM_173359
EIF4E3	hsa-miR-548aa	82.1583	NM_173359
EIF4E3	hsa-miR-548t-3p	82.1583	NM_173359
EIF4E3	hsa-miR-548ap-3p	82.1583	NM_173359
EIF4E3	hsa-miR-627-3p	81.6295	NM_173359
EIF4E3	hsa-miR-3658	80.9399	NM_173359
EIF4E3	hsa-miR-32-3p	80.8595	NM_173359
EIF4E3	hsa-miR-4531	80.7803	NM_173359

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Motifs and transcription factors (TFs) regulating EIF4E3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF4E3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
EIF4E3	transfac_pro__M04617	ZBTB7A (directAnnotation).
EIF4E3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
EIF4E3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
EIF4E3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
EIF4E3	transfac_pro__M07387	ZBTB7A (directAnnotation).
EIF4E3	transfac_pro__M07436	WT1 (directAnnotation).
EIF4E3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
EIF4E3	transfac_pro__M00716	ZBTB14 (directAnnotation).
EIF4E3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
EIF4E3	hdpi__HIP2	UBE2K (directAnnotation).
EIF4E3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
EIF4E3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
EIF4E3	transfac_pro__M04893	TAF1 (directAnnotation).
EIF4E3	transfac_pro__M03876	ZBTB33 (directAnnotation).
EIF4E3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
EIF4E3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
EIF4E3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
EIF4E3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
EIF4E3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."