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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: EIF4A1

Summary for EIF4A1

Gene informationGene symbol

EIF4A1

Ensembl ID

ENSG00000161960

Entrez ID

1973

Gene nameeukaryotic translation initiation factor 4A1
SynonymsDDX2A|EIF-4A|EIF4A
Gene typeprotein_coding
UniProtAcc

P60842


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Dataset with differentially expressed gene: EIF4A1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-1.134810.00e+00

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.4822830.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreNK cells-0.2640782.50e-24

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.2590660.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostcDCs-0.2524764.66e-07

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostErythrocytes0.582187.50e-03

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells-0.2979351.23e-30

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells-0.4307060.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD8+ T cells-0.2581411.68e-04

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells-0.3179794.43e-14

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells-0.5265381.65e-36

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells1.183220.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreB cells-0.2685621.08e-11

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells-0.263460.00e+00

GSE164897_VemTra

A375 cell lineCell lineMelanomaB+E2:E57RAFV600E-mutant melanomaTargeted therapyvemurafenib + trametinibNAMalignant cells-0.4575290.00e+00

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Expression of EIF4A1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to EIF4A1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

EIF4A1

Unusual Activation of Pro-survival Pathway
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MicroRNAs (miRNA) regulating EIF4A1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
EIF4A1hsa-miR-3152-5p95.4498NM_001204510
EIF4A1hsa-miR-1212395.3813NM_001204510
EIF4A1hsa-miR-892c-5p94.1717NM_001204510
EIF4A1hsa-miR-133b93.2667NM_001204510
EIF4A1hsa-miR-133a-3p93.2667NM_001204510
EIF4A1hsa-miR-5010-3p92.4414NM_001416
EIF4A1hsa-miR-3691-3p92.2963NM_001416
EIF4A1hsa-miR-95-5p90.5987NM_001416
EIF4A1hsa-miR-3140-5p89.2878NM_001416
EIF4A1hsa-miR-6851-5p89.0908NM_001204510
EIF4A1hsa-miR-3689d89.0908NM_001204510
EIF4A1hsa-miR-128488.0009NM_001416
EIF4A1hsa-miR-670-3p85.5701NM_001204510
EIF4A1hsa-miR-6740-3p83.6644NM_001204510
EIF4A1hsa-miR-449582.6946NM_001416
EIF4A1hsa-miR-1236-5p80.8601NM_001416
EIF4A1hsa-miR-548t-5p80.6792NM_001416
EIF4A1hsa-miR-548az-5p80.6792NM_001416
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Motifs and transcription factors (TFs) regulating EIF4A1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
EIF4A1taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAPELK1; TEF (directAnnotation).
EIF4A1taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAPCEBPD; ETV5 (directAnnotation).
EIF4A1taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAPCEBPD; ERF (directAnnotation).
EIF4A1transfac_pro__M05935ZNF382 (directAnnotation).
EIF4A1jaspar__MA1933.1SREBF2 (directAnnotation).
EIF4A1taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
EIF4A1metacluster_33.8BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
EIF4A1metacluster_141.6MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
EIF4A1taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
EIF4A1transfac_pro__M06259ZNF91 (directAnnotation).
EIF4A1transfac_pro__M06724ZNF331 (directAnnotation).
EIF4A1homer__ATTGCGCAAC_CEBPCEBPB (inferredBy_Orthology).
EIF4A1metacluster_72.11ZNF430 (directAnnotation).
EIF4A1taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAPCEBPD; FLI1 (directAnnotation).
EIF4A1kznf__MZF1_Najafabadi2015_ChIP-seqMZF1 (directAnnotation).
EIF4A1transfac_pro__M06130ZNF254 (directAnnotation).
EIF4A1transfac_pro__M05364ZNF146 (directAnnotation).
EIF4A1transfac_pro__M06486ZNF610 (directAnnotation).
EIF4A1transfac_pro__M04887TCF12 (directAnnotation).
EIF4A1swissregulon__mm__Zbtb12ZBTB12 (inferredBy_Orthology).
EIF4A1tfdimers__MD00349GABPA; YY2 (directAnnotation).
EIF4A1taipale_tf_pairs__ELF2_NATGCGGAAGTR_HTELF2 (directAnnotation).
EIF4A1transfac_pro__M06258ZNF345 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
EIF4A1"Copper"

DB09130

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."