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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: EIF2AK1

Summary for EIF2AK1

Gene information	Gene symbol	EIF2AK1
	Ensembl ID	ENSG00000086232
	Entrez ID	27102
	Gene name	eukaryotic translation initiation factor 2 alpha kinase 1
	Synonyms	HCR\|hHRI\|HRI\|KIAA1369
	Gene type	protein_coding
	UniProtAcc	Q9BQI3

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Dataset with differentially expressed gene: EIF2AK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.338211	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.37875	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.289154	2.16e-05
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.31847	9.75e-15
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.253263	2.31e-31

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Expression of EIF2AK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF2AK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF2AK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF2AK1	hsa-miR-30a-3p	96.8038	NM_001134335
EIF2AK1	hsa-miR-30e-3p	96.8038	NM_001134335
EIF2AK1	hsa-miR-30d-3p	96.8038	NM_001134335
EIF2AK1	hsa-miR-4306	91.3466	NM_001134335
EIF2AK1	hsa-miR-584-5p	89.1355	NM_001134335
EIF2AK1	hsa-miR-4448	89.0756	NM_001134335
EIF2AK1	hsa-miR-4644	87.8884	NM_001134335
EIF2AK1	hsa-miR-185-5p	87.8884	NM_001134335
EIF2AK1	hsa-miR-514b-5p	86.7363	NM_001134335
EIF2AK1	hsa-miR-513c-5p	86.7363	NM_001134335
EIF2AK1	hsa-miR-520g-5p	86.4075	NM_001134335
EIF2AK1	hsa-miR-5589-5p	84.1598	NM_001134335
EIF2AK1	hsa-miR-6132	82.8064	NM_001134335
EIF2AK1	hsa-miR-6836-5p	82.8064	NM_001134335
EIF2AK1	hsa-miR-302c-5p	82.7699	NM_001134335
EIF2AK1	hsa-miR-6081	80.9203	NM_001134335
EIF2AK1	hsa-miR-4473	80.0905	NM_001134335

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Motifs and transcription factors (TFs) regulating EIF2AK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF2AK1	jaspar__MA1483.2	ELF2 (directAnnotation).
EIF2AK1	metacluster_151.2	ZNF23 (directAnnotation).
EIF2AK1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
EIF2AK1	hdpi__ETV4	ETV4 (directAnnotation).
EIF2AK1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
EIF2AK1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EIF2AK1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
EIF2AK1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
EIF2AK1	cisbp__M08198	ELF1 (directAnnotation).
EIF2AK1	transfac_pro__M00652	NRF1 (directAnnotation).
EIF2AK1	transfac_pro__M04866	HDAC2 (directAnnotation).
EIF2AK1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EIF2AK1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
EIF2AK1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
EIF2AK1	cisbp__M02645	ETS1 (directAnnotation).
EIF2AK1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
EIF2AK1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
EIF2AK1	transfac_pro__M05712	ZNF134 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
EIF2AK1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."