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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EIF1AX

Summary for EIF1AX

Gene information	Gene symbol	EIF1AX
	Ensembl ID	ENSG00000173674
	Entrez ID	1964
	Gene name	eukaryotic translation initiation factor 1A X-linked
	Synonyms	eIF-1A\|eIF-4C\|EIF1A\|EIF4C
	Gene type	protein_coding
	UniProtAcc	P47813

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Dataset with differentially expressed gene: EIF1AX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	1.05105	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.416514	4.20e-37
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.295647	1.98e-10
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.346203	9.57e-19
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.270008	1.49e-13
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.34489	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.495306	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.252599	1.65e-42
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.396164	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.377551	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.335181	1.08e-39
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.821014	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-1.06266	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.8493	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.710222	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.252381	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.344451	0.00e+00

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Expression of EIF1AX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF1AX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF1AX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF1AX	hsa-miR-8063	99.9089	NM_001412
EIF1AX	hsa-miR-4698	98.924	NM_001412
EIF1AX	hsa-miR-3163	98.3479	NM_001412
EIF1AX	hsa-miR-10527-5p	97.2703	NM_001412
EIF1AX	hsa-miR-5011-5p	96.4732	NM_001412
EIF1AX	hsa-miR-206	95.3096	NM_001412
EIF1AX	hsa-miR-1-3p	95.3096	NM_001412
EIF1AX	hsa-miR-217-3p	94.3791	NM_001412
EIF1AX	hsa-miR-613	94.05	NM_001412
EIF1AX	hsa-miR-1252-3p	92.6932	NM_001412
EIF1AX	hsa-miR-4666a-5p	92.1095	NM_001412
EIF1AX	hsa-miR-6507-5p	89.7953	NM_001412
EIF1AX	hsa-miR-7159-5p	89.7632	NM_001412
EIF1AX	hsa-miR-190a-3p	89.5326	NM_001412
EIF1AX	hsa-miR-4328	89.4533	NM_001412
EIF1AX	hsa-miR-1278	88.8762	NM_001412
EIF1AX	hsa-miR-548p	88.842	NM_001412
EIF1AX	hsa-miR-6868-3p	88.6929	NM_001412
EIF1AX	hsa-miR-200b-5p	88.519	NM_001412
EIF1AX	hsa-miR-200a-5p	88.519	NM_001412
EIF1AX	hsa-miR-3613-3p	88.2367	NM_001412
EIF1AX	hsa-miR-323a-3p	87.614	NM_001412
EIF1AX	hsa-miR-4495	87.3567	NM_001412
EIF1AX	hsa-miR-607	87.3317	NM_001412
EIF1AX	hsa-miR-3658	86.4311	NM_001412
EIF1AX	hsa-miR-27a-5p	86.2882	NM_001412
EIF1AX	hsa-miR-676-5p	86.2645	NM_001412
EIF1AX	hsa-miR-3671	86.1833	NM_001412
EIF1AX	hsa-miR-335-3p	86.1814	NM_001412
EIF1AX	hsa-miR-4420	85.7214	NM_001412
EIF1AX	hsa-miR-181b-3p	85.7214	NM_001412
EIF1AX	hsa-miR-181b-2-3p	85.7214	NM_001412
EIF1AX	hsa-miR-381-3p	85.3521	NM_001412
EIF1AX	hsa-miR-300	85.3521	NM_001412
EIF1AX	hsa-miR-3662	84.7038	NM_001412
EIF1AX	hsa-miR-548bb-3p	83.9007	NM_001412
EIF1AX	hsa-miR-548z	83.9007	NM_001412
EIF1AX	hsa-miR-548ac	83.9007	NM_001412
EIF1AX	hsa-miR-548d-3p	83.9007	NM_001412
EIF1AX	hsa-miR-548h-3p	83.9007	NM_001412
EIF1AX	hsa-miR-653-5p	83.5148	NM_001412
EIF1AX	hsa-miR-885-5p	82.8741	NM_001412
EIF1AX	hsa-miR-5571-3p	82.8054	NM_001412
EIF1AX	hsa-miR-4744	82.3495	NM_001412
EIF1AX	hsa-miR-4310	82.0075	NM_001412
EIF1AX	hsa-miR-4426	80.9265	NM_001412
EIF1AX	hsa-miR-3646	80.1348	NM_001412
EIF1AX	hsa-miR-3144-3p	80.0811	NM_001412

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Motifs and transcription factors (TFs) regulating EIF1AX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF1AX	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
EIF1AX	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EIF1AX	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
EIF1AX	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
EIF1AX	jaspar__MA1122.1	TFDP1 (directAnnotation).
EIF1AX	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EIF1AX	transfac_pro__M04748	GABPA (directAnnotation).
EIF1AX	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
EIF1AX	transfac_pro__M04944	GABPA (directAnnotation).
EIF1AX	metacluster_141.2	E2F2; E2F3 (directAnnotation).
EIF1AX	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
EIF1AX	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
EIF1AX	jaspar__MA0748.2	YY2 (directAnnotation).
EIF1AX	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
EIF1AX	metacluster_172.6	CHD2; E2F1 (directAnnotation).
EIF1AX	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
EIF1AX	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
EIF1AX	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
EIF1AX	transfac_pro__M02913	SP140 (inferredBy_Orthology).
EIF1AX	transfac_pro__M00430	E2F1 (directAnnotation).
EIF1AX	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
EIF1AX	transfac_pro__M00938	E2F1 (directAnnotation).
EIF1AX	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EIF1AX	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
EIF1AX	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
EIF1AX	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
EIF1AX	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
EIF1AX	transfac_pro__M05427	ZNF516 (directAnnotation).
EIF1AX	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
EIF1AX	transfac_pro__M06032	ZNF727 (directAnnotation).
EIF1AX	transfac_pro__M06432	ZNF571 (directAnnotation).
EIF1AX	metacluster_161.16	NKX3-2 (directAnnotation).
EIF1AX	transfac_pro__M05944	ZNF552 (directAnnotation).
EIF1AX	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
EIF1AX	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
EIF1AX	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
EIF1AX	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
EIF1AX	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
EIF1AX	transfac_pro__M04817	ZBTB33 (directAnnotation).
EIF1AX	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
EIF1AX	transfac_pro__M02090	E2F4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."