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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor

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Acts as a drug target< (This gene does not contain this module)

Gene: EHF

Summary for EHF

Gene informationGene symbol

EHF

Ensembl ID

ENSG00000135373

Entrez ID

26298

Gene nameETS homologous factor
SynonymsESE3|ESEJ
Gene typeprotein_coding
UniProtAcc

Q9NZC4


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Dataset with differentially expressed gene: EHF

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE138267

CDXTumor tissueLung cancerSmall cell lung cancer (SCLC)ChemotherapyNANAMalignant cells-0.4996690.00e+00

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.3565450.00e+00

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.8259310.00e+00

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells-1.153070.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.2810023.86e-14

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Expression of EHF in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to EHF

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

EHF

Unusual Activation of Pro-survival Pathway
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MicroRNAs (miRNA) regulating EHF

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
EHFhsa-miR-124897.6945NM_001206616
EHFhsa-miR-998597.0717NM_001206615
EHFhsa-miR-27b-3p97.0717NM_001206615
EHFhsa-miR-27a-3p97.0717NM_001206615
EHFhsa-miR-6868-3p96.757NM_001206616
EHFhsa-miR-597-3p94.918NM_001206615
EHFhsa-miR-3121-3p94.27NM_001206615
EHFhsa-miR-130593.3614NM_001206615
EHFhsa-miR-29a-5p92.7794NM_001206616
EHFhsa-miR-224-5p90.5617NM_001206615
EHFhsa-miR-3691-3p90.3112NM_001206615
EHFhsa-miR-365b-3p89.8466NM_001206615
EHFhsa-miR-365a-3p89.8466NM_001206615
EHFhsa-miR-4762-3p89.7725NM_001206616
EHFhsa-miR-342-3p89.5934NM_001206615
EHFhsa-miR-5692a88.9541NM_001206616
EHFhsa-miR-6875-3p88.6446NM_001206615
EHFhsa-miR-335-3p88.3776NM_001206615
EHFhsa-miR-616588.2464NM_001206616
EHFhsa-miR-684487.5904NM_001206616
EHFhsa-miR-4766-3p86.3182NM_001206616
EHFhsa-miR-4659b-3p85.6048NM_001206615
EHFhsa-miR-4659a-3p85.6048NM_001206615
EHFhsa-miR-6826-3p85.5165NM_001206616
EHFhsa-miR-80283.7996NM_001206616
EHFhsa-miR-627-3p83.6841NM_001206616
EHFhsa-miR-513b-5p83.3403NM_001206615
EHFhsa-miR-430882.9856NM_001206616
EHFhsa-miR-3681-3p81.9154NM_001206615
EHFhsa-miR-391981.8074NM_001206616
EHFhsa-miR-428781.2868NM_001206616
EHFhsa-miR-4685-3p81.2868NM_001206616
EHFhsa-miR-892a81.1379NM_001206615
EHFhsa-miR-3692-3p80.8759NM_001206616
EHFhsa-miR-3059-5p80.6008NM_001206616
EHFhsa-miR-302c-5p80.3566NM_001206616
EHFhsa-miR-392080.3461NM_001206616
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Motifs and transcription factors (TFs) regulating EHF

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
EHFtransfac_pro__M06864ZNF585B (directAnnotation).
EHFtransfac_pro__M06564ZNF578 (directAnnotation).
EHFtransfac_pro__M05670ZNF37A (directAnnotation).
EHFtaipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_reprERF; HOXA3 (directAnnotation).
EHFmetacluster_174.3MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
EHFmetacluster_174.2CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
EHFtaipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAPELK3; HOXB2 (directAnnotation).
EHFtaipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_reprDRGX; ETV2 (directAnnotation).
EHFjaspar__MA1957.1ELK1 (directAnnotation).
EHFtaipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.
TFmotifExpressionCell typeDatasetTimepoint
EHFmetacluster_191.3upMalignant cells

GSE139386

NA
EHFmetacluster_166.4upMalignant cells

GSE139386

NA
EHFmetacluster_191.3downMalignant cells

GSE163836

NA
EHFmetacluster_166.4downMalignant cells

GSE163836

NA
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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."