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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EHBP1

Summary for EHBP1

Gene information	Gene symbol	EHBP1
	Ensembl ID	ENSG00000115504
	Entrez ID	23301
	Gene name	EH domain binding protein 1
	Synonyms	KIAA0903\|NACSIN
	Gene type	protein_coding
	UniProtAcc	Q8NDI1

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Dataset with differentially expressed gene: EHBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.501468	4.39e-37

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Expression of EHBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EHBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EHBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EHBP1	hsa-miR-513a-5p	93.5168	NM_001142614
EHBP1	hsa-miR-4282	93.2924	NM_001142614
EHBP1	hsa-miR-6830-5p	92.9877	NM_001142614
EHBP1	hsa-miR-31-3p	92.1783	NM_001142614
EHBP1	hsa-miR-2054	91.8776	NM_001142614
EHBP1	hsa-miR-570-5p	91.336	NM_001142614
EHBP1	hsa-miR-548ag	91.336	NM_001142614
EHBP1	hsa-miR-548ai	91.336	NM_001142614
EHBP1	hsa-miR-6750-3p	90.7599	NM_001142614
EHBP1	hsa-miR-548ba	90.6597	NM_001142614
EHBP1	hsa-miR-3529-3p	88.2536	NM_001142614
EHBP1	hsa-miR-6509-5p	87.8586	NM_001142614
EHBP1	hsa-miR-3613-3p	87.7396	NM_001142614
EHBP1	hsa-miR-16-1-3p	87.4268	NM_001142614
EHBP1	hsa-miR-3167	86.5048	NM_001142614
EHBP1	hsa-miR-19a-3p	86.5033	NM_001142614
EHBP1	hsa-miR-19b-3p	86.5033	NM_001142614
EHBP1	hsa-miR-6720-5p	85.1432	NM_001142614
EHBP1	hsa-miR-6512-3p	85.1432	NM_001142614
EHBP1	hsa-miR-5692a	85.1394	NM_001142614
EHBP1	hsa-miR-7111-3p	84.5998	NM_001142614
EHBP1	hsa-miR-3146	83.5368	NM_001142614
EHBP1	hsa-miR-6715b-3p	83.2923	NM_001142614
EHBP1	hsa-miR-876-5p	82.9866	NM_001142614
EHBP1	hsa-miR-3163	81.4941	NM_001142614
EHBP1	hsa-miR-500a-5p	81.1006	NM_001142614
EHBP1	hsa-miR-561-3p	80.8474	NM_001142614
EHBP1	hsa-miR-561-5p	80.1479	NM_001142614

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Motifs and transcription factors (TFs) regulating EHBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EHBP1	transfac_pro__M05976	ZNF223 (directAnnotation).
EHBP1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EHBP1	metacluster_141.4	GLIS2 (directAnnotation).
EHBP1	transfac_pro__M06249	ZNF616 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."