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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EFNA5

Summary for EFNA5

Gene information	Gene symbol	EFNA5
	Ensembl ID	ENSG00000184349
	Entrez ID	1946
	Gene name	ephrin A5
	Synonyms	AF1\|EPLG7\|LERK7
	Gene type	protein_coding
	UniProtAcc	P52803

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Dataset with differentially expressed gene: EFNA5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.53775	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.439815	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.459365	0.00e+00

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Expression of EFNA5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EFNA5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EFNA5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EFNA5	hsa-miR-1289	97.4564	NM_001962
EFNA5	hsa-miR-7978	96.3094	NM_001962
EFNA5	hsa-miR-1290	96.1047	NM_001962
EFNA5	hsa-miR-6733-5p	96.0045	NM_001962
EFNA5	hsa-miR-6739-5p	96.0045	NM_001962
EFNA5	hsa-miR-361-3p	95.5329	NM_001962
EFNA5	hsa-miR-6747-5p	95.3475	NM_001962
EFNA5	hsa-miR-6815-3p	95.2534	NM_001962
EFNA5	hsa-miR-5681a	95.1261	NM_001962
EFNA5	hsa-miR-26a-2-3p	94.9857	NM_001962
EFNA5	hsa-miR-26a-1-3p	94.9857	NM_001962
EFNA5	hsa-miR-3153	94.9379	NM_001962
EFNA5	hsa-miR-5088-3p	94.7467	NM_001962
EFNA5	hsa-miR-6756-5p	93.2409	NM_001962
EFNA5	hsa-miR-3198	92.7383	NM_001962
EFNA5	hsa-miR-1250-3p	92.7053	NM_001962
EFNA5	hsa-miR-4799-5p	92.6218	NM_001962
EFNA5	hsa-miR-3910	92.2897	NM_001962
EFNA5	hsa-miR-4309	92.1157	NM_001962
EFNA5	hsa-miR-576-5p	92.0796	NM_001962
EFNA5	hsa-miR-369-3p	91.9229	NM_001962
EFNA5	hsa-miR-6766-5p	91.1808	NM_001962
EFNA5	hsa-miR-4668-5p	91.0634	NM_001962
EFNA5	hsa-miR-4651	90.8202	NM_001962
EFNA5	hsa-miR-370-5p	90.4252	NM_001962
EFNA5	hsa-miR-570-3p	90.3684	NM_001962
EFNA5	hsa-miR-4775	90.0243	NM_001962
EFNA5	hsa-miR-548g-3p	89.9496	NM_001962
EFNA5	hsa-miR-3613-3p	89.1007	NM_001962
EFNA5	hsa-miR-374c-5p	89.073	NM_001962
EFNA5	hsa-miR-608	88.9213	NM_001962
EFNA5	hsa-miR-527	88.8531	NM_001962
EFNA5	hsa-miR-518a-5p	88.8531	NM_001962
EFNA5	hsa-miR-4482-3p	88.5385	NM_001962
EFNA5	hsa-miR-4294	88.4275	NM_001962
EFNA5	hsa-miR-4755-5p	87.9715	NM_001962
EFNA5	hsa-miR-5006-3p	87.9715	NM_001962
EFNA5	hsa-miR-4263	87.7093	NM_001962
EFNA5	hsa-miR-4679	87.5842	NM_001962
EFNA5	hsa-miR-6781-3p	87.3403	NM_001962
EFNA5	hsa-miR-7110-5p	86.9402	NM_001962
EFNA5	hsa-miR-6842-5p	86.9402	NM_001962
EFNA5	hsa-miR-1303	86.7851	NM_001962
EFNA5	hsa-miR-3662	86.6183	NM_001962
EFNA5	hsa-miR-2114-5p	86.5802	NM_001962
EFNA5	hsa-miR-6866-5p	86.42	NM_001962
EFNA5	hsa-miR-3913-5p	86.3914	NM_001962
EFNA5	hsa-miR-605-3p	86.3869	NM_001962
EFNA5	hsa-miR-6760-5p	86.38	NM_001962
EFNA5	hsa-miR-655-3p	85.6272	NM_001962

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Motifs and transcription factors (TFs) regulating EFNA5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EFNA5	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
EFNA5	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EFNA5	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
EFNA5	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
EFNA5	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
EFNA5	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
EFNA5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
EFNA5	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
EFNA5	metacluster_3.14	WT1; WT1 (directAnnotation).
EFNA5	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EFNA5	cisbp__M07938	E2F1 (directAnnotation).
EFNA5	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
EFNA5	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
EFNA5	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
EFNA5	transfac_pro__M04950	EGR1 (directAnnotation).
EFNA5	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EFNA5	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
EFNA5	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
EFNA5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
EFNA5	transfac_pro__M00652	NRF1 (directAnnotation).
EFNA5	hdpi__ETV4	ETV4 (directAnnotation).
EFNA5	transfac_pro__M04866	HDAC2 (directAnnotation).
EFNA5	jaspar__MA1122.1	TFDP1 (directAnnotation).
EFNA5	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
EFNA5	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
EFNA5	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
EFNA5	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
EFNA5	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
EFNA5	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
EFNA5	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
EFNA5	transfac_pro__M02089	E2F3 (directAnnotation).
EFNA5	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
EFNA5	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
EFNA5	transfac_pro__M04817	ZBTB33 (directAnnotation).
EFNA5	metacluster_143.13	ZBTB7A (directAnnotation).
EFNA5	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
EFNA5	tfdimers__MD00483	ZBTB14 (directAnnotation).
EFNA5	cisbp__M00968	MTF2 (directAnnotation).
EFNA5	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
EFNA5	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
EFNA5	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."