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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EFNA3

Summary for EFNA3

Gene information	Gene symbol	EFNA3
	Ensembl ID	ENSG00000143590
	Entrez ID	1944
	Gene name	ephrin A3
	Synonyms	Ehk1-L\|EPLG3\|LERK3
	Gene type	protein_coding
	UniProtAcc	P52797

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Dataset with differentially expressed gene: EFNA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.42294	0.00e+00

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Expression of EFNA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EFNA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EFNA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EFNA3	hsa-miR-6817-3p	93.5019	NM_004952
EFNA3	hsa-miR-190a-3p	93.1154	NM_004952
EFNA3	hsa-miR-1913	91.5668	NM_004952
EFNA3	hsa-miR-6887-5p	91.1142	NM_004952
EFNA3	hsa-miR-3202	89.5612	NM_004952
EFNA3	hsa-miR-330-5p	89.5401	NM_004952
EFNA3	hsa-miR-7702	89.2724	NM_004952
EFNA3	hsa-miR-3925-3p	89.1953	NM_004952
EFNA3	hsa-miR-30c-5p	87.4995	NM_004952
EFNA3	hsa-miR-30b-5p	87.4995	NM_004952
EFNA3	hsa-miR-30a-5p	87.4995	NM_004952
EFNA3	hsa-miR-30d-5p	87.4995	NM_004952
EFNA3	hsa-miR-30e-5p	87.4995	NM_004952
EFNA3	hsa-miR-6795-5p	87.4489	NM_004952
EFNA3	hsa-miR-493-5p	87.3381	NM_004952
EFNA3	hsa-miR-3179	85.9776	NM_004952
EFNA3	hsa-miR-3976	85.8488	NM_004952
EFNA3	hsa-miR-92a-2-5p	84.7257	NM_004952
EFNA3	hsa-miR-5007-5p	84.207	NM_004952
EFNA3	hsa-miR-6798-5p	83.5029	NM_004952
EFNA3	hsa-miR-1537-5p	83.4498	NM_004952
EFNA3	hsa-miR-4758-3p	83.239	NM_004952
EFNA3	hsa-miR-326	82.39	NM_004952
EFNA3	hsa-miR-5011-5p	82.2498	NM_004952
EFNA3	hsa-miR-4271	80.5685	NM_004952
EFNA3	hsa-miR-6780b-5p	80.1327	NM_004952
EFNA3	hsa-miR-4725-3p	80.1327	NM_004952

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Motifs and transcription factors (TFs) regulating EFNA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EFNA3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
EFNA3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
EFNA3	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."