Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EFNA1

Summary for EFNA1

Gene information	Gene symbol	EFNA1
	Ensembl ID	ENSG00000169242
	Entrez ID	1942
	Gene name	ephrin A1
	Synonyms	ECKLG\|EPLG1\|GMAN\|LERK1\|TNFAIP4
	Gene type	protein_coding
	UniProtAcc	P20827

Top

Dataset with differentially expressed gene: EFNA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.350743	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.428611	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.8422	0.00e+00

Top

Expression of EFNA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to EFNA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating EFNA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EFNA1	hsa-miR-18a-3p	96.9489	NM_004428
EFNA1	hsa-miR-6893-5p	91.3596	NM_004428
EFNA1	hsa-miR-6808-5p	91.3596	NM_004428
EFNA1	hsa-miR-568	90.1431	NM_004428
EFNA1	hsa-miR-940	88.389	NM_004428
EFNA1	hsa-miR-4307	84.7363	NM_004428
EFNA1	hsa-miR-938	84.2721	NM_004428
EFNA1	hsa-miR-1185-2-3p	82.2032	NM_004428
EFNA1	hsa-miR-1185-1-3p	82.2032	NM_004428
EFNA1	hsa-let-7f-2-3p	82.2032	NM_004428
EFNA1	hsa-miR-9-5p	81.525	NM_004428
EFNA1	hsa-miR-485-5p	81.1682	NM_004428
EFNA1	hsa-miR-6884-5p	81.1682	NM_004428
EFNA1	hsa-miR-8085	81.0716	NM_004428
EFNA1	hsa-miR-6731-5p	81.0716	NM_004428

Page: 1

Top

Motifs and transcription factors (TFs) regulating EFNA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EFNA1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
EFNA1	transfac_pro__M00652	NRF1 (directAnnotation).
EFNA1	transfac_pro__M05427	ZNF516 (directAnnotation).
EFNA1	transfac_pro__M06109	ZNF254 (directAnnotation).
EFNA1	transfac_pro__M06135	ZNF28 (directAnnotation).
EFNA1	transfac_pro__M06141	ZNF708 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."