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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EFHC1

Summary for EFHC1

Gene information	Gene symbol	EFHC1
	Ensembl ID	ENSG00000096093
	Entrez ID	114327
	Gene name	EF-hand domain containing 1
	Synonyms	EJM\|EJM1\|FLJ10466\|POC9\|RIB72
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EFHC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.738281	2.52e-03
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.493241	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.268699	0.00e+00

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Expression of EFHC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EFHC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EFHC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EFHC1	hsa-miR-5011-5p	99.7664	NM_018100
EFHC1	hsa-miR-190a-3p	99.4611	NM_018100
EFHC1	hsa-miR-4433b-3p	97.2248	NM_018100
EFHC1	hsa-miR-520f-5p	94.997	NM_018100
EFHC1	hsa-miR-6823-5p	93.7294	NM_018100
EFHC1	hsa-miR-4443	89.0322	NM_018100
EFHC1	hsa-miR-4534	88.552	NM_018100
EFHC1	hsa-miR-590-3p	83.2403	NM_018100
EFHC1	hsa-miR-5196-5p	82.99	NM_018100
EFHC1	hsa-miR-1827	82.8114	NM_018100
EFHC1	hsa-miR-6818-3p	82.3282	NM_018100
EFHC1	hsa-miR-4509	82.2395	NM_018100
EFHC1	hsa-miR-1283	80.8094	NM_018100
EFHC1	hsa-miR-8082	80.4632	NM_018100
EFHC1	hsa-miR-7160-5p	80.0314	NM_018100

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Motifs and transcription factors (TFs) regulating EFHC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EFHC1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
EFHC1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
EFHC1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
EFHC1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
EFHC1	transfac_pro__M01714	KLF15 (directAnnotation).
EFHC1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
EFHC1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
EFHC1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
EFHC1	transfac_pro__M02898	SMAD3 (directAnnotation).
EFHC1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
EFHC1	hdpi__HIP2	UBE2K (directAnnotation).
EFHC1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."