DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: EFEMP1

Summary for EFEMP1

Gene informationGene symbol

EFEMP1

Ensembl ID

ENSG00000115380

Entrez ID

2202

Gene nameEGF containing fibulin extracellular matrix protein 1
SynonymsDHRD|FBLN3|FBNL|MTLV|S1-5
Gene typeprotein_coding
UniProtAcc

Q12805


Top

Dataset with differentially expressed gene: EFEMP1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.3156610.00e+00

Top

Expression of EFEMP1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to EFEMP1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating EFEMP1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
EFEMP1hsa-miR-474496.1813NM_001039348
EFEMP1hsa-miR-450995.6054NM_001039348
EFEMP1hsa-miR-144-3p94.9258NM_001039349
EFEMP1hsa-miR-4735-5p93.1433NM_001039348
EFEMP1hsa-miR-1250-3p93.1021NM_001039349
EFEMP1hsa-miR-316392.648NM_001039348
EFEMP1hsa-miR-4799-5p92.0771NM_001039348
EFEMP1hsa-miR-320191.9827NM_001039349
EFEMP1hsa-miR-524-5p91.8859NM_001039348
EFEMP1hsa-miR-520d-5p91.8859NM_001039348
EFEMP1hsa-miR-548d-3p89.5691NM_001039348
EFEMP1hsa-miR-539-5p89.0938NM_001039349
EFEMP1hsa-miR-548z88.5586NM_001039348
EFEMP1hsa-miR-548bb-3p88.5586NM_001039348
EFEMP1hsa-miR-548h-3p88.5586NM_001039348
EFEMP1hsa-miR-548ac88.5586NM_001039348
EFEMP1hsa-miR-548ba88.4402NM_001039349
EFEMP1hsa-miR-548ai88.4402NM_001039349
EFEMP1hsa-miR-570-5p88.4402NM_001039349
EFEMP1hsa-miR-548ag88.4402NM_001039349
EFEMP1hsa-miR-548x-3p86.67NM_001039348
EFEMP1hsa-miR-548aj-3p86.67NM_001039348
EFEMP1hsa-let-7a-2-3p86.4872NM_001039348
EFEMP1hsa-let-7g-3p86.4872NM_001039348
EFEMP1hsa-miR-32-3p86.4675NM_001039348
EFEMP1hsa-miR-479186.4198NM_001039349
EFEMP1hsa-miR-520f-3p86.0748NM_001039349
EFEMP1hsa-miR-584-3p85.7129NM_001039349
EFEMP1hsa-miR-6885-3p84.8169NM_001039349
EFEMP1hsa-miR-5692a84.7316NM_001039348
EFEMP1hsa-miR-3681-5p84.4261NM_001039348
EFEMP1hsa-miR-873-3p83.8904NM_001039349
EFEMP1hsa-miR-1211582.5674NM_001039348
EFEMP1hsa-miR-548am-3p82.5373NM_001039348
EFEMP1hsa-miR-548ah-3p82.5373NM_001039348
EFEMP1hsa-miR-548ae-3p82.5373NM_001039348
EFEMP1hsa-miR-548aq-3p82.5373NM_001039348
EFEMP1hsa-miR-548j-3p82.5373NM_001039348
EFEMP1hsa-miR-463582.4551NM_001039348
EFEMP1hsa-miR-498-3p82.4395NM_001039349
EFEMP1hsa-miR-64781.942NM_001039348
EFEMP1hsa-miR-6842-3p81.8159NM_001039348
EFEMP1hsa-miR-6849-5p80.7537NM_001039348
EFEMP1hsa-miR-365a-3p80.0167NM_001039349
EFEMP1hsa-miR-365b-3p80.0167NM_001039349
Page: 1

Top

Motifs and transcription factors (TFs) regulating EFEMP1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
EFEMP1taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_reprE2F2 (directAnnotation).
EFEMP1taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
EFEMP1transfac_pro__M04866HDAC2 (directAnnotation).
EFEMP1swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."