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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EFCAB14

Summary for EFCAB14

Gene information	Gene symbol	EFCAB14
	Ensembl ID	ENSG00000159658
	Entrez ID	9813
	Gene name	EF-hand calcium binding domain 14
	Synonyms	KIAA0494
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EFCAB14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.33814	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.255191	2.15e-20

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Expression of EFCAB14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EFCAB14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EFCAB14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EFCAB14	hsa-miR-106b-5p	96.8225	NM_014774
EFCAB14	hsa-miR-20a-5p	96.8225	NM_014774
EFCAB14	hsa-miR-345-3p	95.4938	NM_014774
EFCAB14	hsa-miR-526b-3p	95.4885	NM_014774
EFCAB14	hsa-miR-93-5p	95.4885	NM_014774
EFCAB14	hsa-miR-519d-3p	95.4885	NM_014774
EFCAB14	hsa-miR-17-5p	95.4885	NM_014774
EFCAB14	hsa-miR-20b-5p	95.4885	NM_014774
EFCAB14	hsa-miR-106a-5p	95.4885	NM_014774
EFCAB14	hsa-miR-381-3p	94.7558	NM_014774
EFCAB14	hsa-miR-300	94.7558	NM_014774
EFCAB14	hsa-miR-4778-3p	93.3204	NM_014774
EFCAB14	hsa-miR-142-5p	92.141	NM_014774
EFCAB14	hsa-miR-5590-3p	92.141	NM_014774
EFCAB14	hsa-miR-3714	91.9579	NM_014774
EFCAB14	hsa-miR-124-3p	90.2462	NM_014774
EFCAB14	hsa-miR-506-3p	90.2462	NM_014774
EFCAB14	hsa-miR-5011-5p	89.7881	NM_014774
EFCAB14	hsa-miR-137-3p	89.5975	NM_014774
EFCAB14	hsa-miR-7154-3p	88.9186	NM_014774
EFCAB14	hsa-miR-3201	88.8139	NM_014774
EFCAB14	hsa-miR-3910	87.9492	NM_014774
EFCAB14	hsa-miR-302d-5p	87.4485	NM_014774
EFCAB14	hsa-miR-302b-5p	87.4485	NM_014774
EFCAB14	hsa-miR-641	86.6266	NM_014774
EFCAB14	hsa-miR-3617-5p	86.6266	NM_014774
EFCAB14	hsa-miR-4303	86.4144	NM_014774
EFCAB14	hsa-miR-3613-3p	86.1616	NM_014774
EFCAB14	hsa-miR-4732-3p	85.9409	NM_014774
EFCAB14	hsa-miR-3128	85.8131	NM_014774
EFCAB14	hsa-miR-3116	85.5485	NM_014774
EFCAB14	hsa-miR-4686	85.4904	NM_014774
EFCAB14	hsa-miR-3121-3p	83.8766	NM_014774
EFCAB14	hsa-miR-6867-3p	83.7669	NM_014774
EFCAB14	hsa-miR-513a-3p	83.7668	NM_014774
EFCAB14	hsa-miR-513c-3p	83.7668	NM_014774
EFCAB14	hsa-miR-4791	82.1949	NM_014774
EFCAB14	hsa-miR-12124	82.0641	NM_014774
EFCAB14	hsa-miR-548v	82.0289	NM_014774
EFCAB14	hsa-miR-5002-5p	81.173	NM_014774
EFCAB14	hsa-miR-659-3p	81.1335	NM_014774
EFCAB14	hsa-miR-7977	81.1134	NM_014774
EFCAB14	hsa-miR-8065	80.5908	NM_014774
EFCAB14	hsa-miR-3944-5p	80.4945	NM_014774

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Motifs and transcription factors (TFs) regulating EFCAB14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EFCAB14	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."